Guilhot F, Dreyfus B, Desmarest M C, Giraud C, Huret J L, Brizard A, Tanzer J
Départment d'Hématologie et Oncologie Médicale, Unité CNRS 223, Hôpital Jean-Bernard, Poitiers, France.
Nouv Rev Fr Hematol (1978). 1989;31(2):171-3.
In view of the results achieved by others with interferons and also with low doses of Cytosine-arabinoside, we have treated 24 patients with IFN alpha 2a and Hydroxyurea for induction, with addition of low dose Ara-C during IFN maintenance therapy when the cytogenetic results were deemed insufficient. Complete hematological responses were obtained in 75% of the cases. Cytogenetic responses were noted in 83% of 12 previously untreated (complete or almost complete response in 3) and in 50% of previously treated patients (complete or almost complete response in 3 patients).
