National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug-resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, China.
Medical Library of Chinese People's Liberation Army, 59th, Middle Section West 4th Ring, Beijing, 100039, China.
J Infect. 2016 Dec;73(6):558-567. doi: 10.1016/j.jinf.2016.08.020. Epub 2016 Oct 4.
Despite increasing attention towards the non-tuberculous mycobacterial (NTM) diseases, the overall epidemiological information remains unavailable for China. A systematic review and meta-analysis was conducted using data of 105 qualified publications from Chinese mainland. The assay demonstrated that the prevalence of NTM infections among tuberculosis suspects was 6.3% (5.4%-7.4%) in mainland, while the Southeastern region had the highest NTM prevalence at 8.6% (7.1%-10.5%). In Northern China, slow growing mycobacteria (SGM) consistituted 63.7% of all the NTM isolates, while this rate in Southern China was 53.0%. More rapid growing mycobacteria (RGM) were present in southern China than the northern (χ = 57.996, P < 0.001). According to the coastal provinces' data (from north to south), the NTM prevalence rate and the number of isolated NTM species increased apparently in accordance with geographic latitude. The information obtained in this assay will facilitate the NTM disease diagnosis and screening policy making in China.
尽管非结核分枝杆菌（NTM）疾病越来越受到关注，但中国的整体流行病学信息仍然缺乏。本研究使用中国大陆 105 篇合格出版物的数据进行了系统评价和荟萃分析。结果表明，在中国大陆，肺结核疑似患者中 NTM 感染的患病率为 6.3%（5.4%-7.4%），而东南部地区的 NTM 患病率最高，为 8.6%（7.1%-10.5%）。在北方，慢生长分枝杆菌（SGM）占所有 NTM 分离株的 63.7%，而在南方这一比例为 53.0%。与北方相比，南方的快速生长分枝杆菌（RGM）更为常见（χ=57.996，P<0.001）。根据沿海省份（从北到南）的数据，NTM 患病率和分离的 NTM 种类数量随着地理纬度的增加而明显增加。本研究结果将有助于中国 NTM 疾病的诊断和筛查政策制定。
