do Vale Sónia, Selinger Lenka, Martins João Martin, Bicho Manuel, do Carmo Isabel, Escera Carles
Institute of Neurosciences, University of Barcelona, Catalonia, Spain; Brainlab-Cognitive Neuroscience Research Group, Department of Clinical Psychology and Psychobiology, University of Barcelona, Catalonia, Spain; Endocrinology University Clinic, Lisbon Medical School, University of Lisbon, Portugal; Endocrinology, Diabetes and Metabolism Department, Santa Maria University Hospital, Lisbon, Portugal.
Institute of Neurosciences, University of Barcelona, Catalonia, Spain; Brainlab-Cognitive Neuroscience Research Group, Department of Clinical Psychology and Psychobiology, University of Barcelona, Catalonia, Spain.
Neurosci Lett. 2016 Nov 10;634:98-103. doi: 10.1016/j.neulet.2016.10.002. Epub 2016 Oct 4.
Several studies have suggested that dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulfate (DHEAS) may enhance working memory and attention, yet current evidence is still inconclusive. The balance between both forms of the hormone might be crucial regarding the effects that DHEA and DHEAS exert on the central nervous system. To test the hypothesis that higher DHEAS-to-DHEA ratios might enhance working memory and/or involuntary attention, we studied the DHEAS-to-DHEA ratio in relation to involuntary attention and working memory processing by recording the electroencephalogram of 22 young women while performing a working memory load task and a task without working memory load in an audio-visual oddball paradigm. DHEA and DHEAS were measured in saliva before each task. We found that a higher DHEAS-to-DHEA ratio was related to enhanced auditory novelty-P3 amplitudes during performance of the working memory task, indicating an increased processing of the distracter, while on the other hand there was no difference in the processing of the visual target. These results suggest that the balance between DHEAS and DHEA levels modulates involuntary attention during the performance of a task with cognitive load without interfering with the processing of the task-relevant visual stimulus.
多项研究表明，脱氢表雄酮（DHEA）和硫酸脱氢表雄酮（DHEAS）可能会增强工作记忆和注意力，但目前的证据仍不确凿。这两种激素形式之间的平衡对于DHEA和DHEAS对中枢神经系统的作用可能至关重要。为了验证较高的DHEAS与DHEA比值可能会增强工作记忆和/或非自愿注意力这一假设，我们通过在视听oddball范式中记录22名年轻女性在执行工作记忆负荷任务和无工作记忆负荷任务时的脑电图，研究了DHEAS与DHEA比值与非自愿注意力和工作记忆处理的关系。在每项任务之前测量唾液中的DHEA和DHEAS。我们发现，较高的DHEAS与DHEA比值与工作记忆任务执行期间听觉新奇性P3波幅增强有关，这表明对干扰物的处理增加，而另一方面，视觉目标的处理没有差异。这些结果表明，DHEAS和DHEA水平之间的平衡在执行有认知负荷的任务期间调节非自愿注意力，而不会干扰与任务相关的视觉刺激的处理。
