Wickstrøm E, Bredesen J E, Gordeladze J
Department of Surgery, Ullevaal Hospital, Oslo, Norway.
Pharmacol Toxicol. 1989 May;64(5):417-20. doi: 10.1111/j.1600-0773.1989.tb00678.x.
Five healthy young volunteers were given flunitrazepam 1 mg, triazolam 0.25 mg or placebo at 2 a.m. or 9 a.m. in a double blind, cross-over study. The aim was to investigate the cyclic variations mainly in residual effects of the drugs, but also in sleep onset latency and pharmacokinetics. The study suggested cyclic variations in mood, psychometric tests and in sleep onset latency.
在一项双盲交叉研究中，五名健康的年轻志愿者于凌晨2点或上午9点服用了1毫克氟硝西泮、0.25毫克三唑仑或安慰剂。目的是主要研究药物残留效应的周期性变化，同时也研究入睡潜伏期和药代动力学的周期性变化。该研究表明情绪、心理测试和入睡潜伏期存在周期性变化。
