氨基葡萄糖诱导黑色素生成中断后培养的B-16黑色素瘤细胞的放射敏感性差异

Differential radiosensitivity in cultured B-16 melanoma cells following interrupted melanogenesis induced by glucosamine.

作者信息

Mileo A M, Mattei E, Fanuele M, Delpino A, Ferrini U

机构信息

Biophysics Laboratory, Regina Elena Cancer Institute, Rome, Italy.

出版信息

Pigment Cell Res. 1989 May-Jun;2(3):167-70. doi: 10.1111/j.1600-0749.1989.tb00182.x.

DOI:10.1111/j.1600-0749.1989.tb00182.x

PMID:2771876

Abstract

The relationship between cell pigmentation and radiosensitivity was investigated in a cell model in which melanogenesis was suppressed by a glycosylation inhibitor. It was found that X-irradiation of melanotic B-16 melanoma cells and their amelanotic counterparts, obtained by glucosamine treatment, showed an inverse correlation between radiosensitivity and melanin contents. Since melanogenesis interruption by glucosamine does not affect the DNA repair capacity of nonpigmented cells, it is likely that intracellular melanins play a role in the relative resistance of pigmented cells to X-irradiation.

摘要

在一个通过糖基化抑制剂抑制黑色素生成的细胞模型中，研究了细胞色素沉着与放射敏感性之间的关系。结果发现，对黑色素瘤B - 16黑色素细胞及其通过氨基葡萄糖处理获得的无黑色素对应细胞进行X射线照射时，放射敏感性与黑色素含量呈负相关。由于氨基葡萄糖导致的黑色素生成中断并不影响无色素细胞的DNA修复能力，因此细胞内黑色素很可能在色素细胞对X射线照射的相对抗性中发挥作用。