Kalousek D K
Department of Pathology, University of British Columbia, Vancouver, Canada.
Prog Clin Biol Res. 1989;311:153-63.
Confined placental mosaicism is tissue specific chromosomal mosaicism arising in both chromosomally normal and abnormal zygotes. Studied by first trimester chorionic villus sampling it has been reported in about 1-2% of human gestations. It is more common in the cytotrophoblast than in placental connective tissue. While intrauterine survival of some chromosomally abnormal embryos and fetuses appears to be significantly enhanced by its presence, the effect of confined placental mosaicism on chromosomally normal fetuses is variable and at present time still unpredictable.
局限性胎盘嵌合体是在染色体正常和异常的受精卵中均出现的组织特异性染色体嵌合体。通过孕早期绒毛取样研究发现，约1%-2%的人类妊娠中存在这种情况。它在细胞滋养层中比在胎盘结缔组织中更常见。虽然其存在似乎显著提高了一些染色体异常胚胎和胎儿的宫内存活率，但局限性胎盘嵌合体对染色体正常胎儿的影响是可变的，目前仍然无法预测。
