Mank R, Kala H, Richter M
Sektion Chemie, Wissenschaftsbereich Pharmazie der Humboldt-Universität zu Berlin.
Pharmazie. 1989 Apr;44(4):276-9.
Biodegradable polymers get more interest for the preparation of drug formulations. Their main advantage is their physiological safety. Polylactic acid is one of the biodegradable polymers. It was prepared by the direct polyesterification of lactic acid and by polymerisation of the cyclic oligomers. Both the polymers were identified by elementary analysis, by IR spectroscopy, by X-ray-test and by the molecular mass. They differ in their molecular mass and in the degree of the crystalline state. The determination of the grain size, moisture content, flowability and of the parameters for the direct compression were carried out with regard to the use of polylactic acid as auxiliary substance for the direct compression. The results show, that polylactic acid which was prepared on the basis of polyesterification, is a very suitable auxiliary substance for the direct compression.
可生物降解聚合物在药物制剂制备方面备受关注。它们的主要优点是生理安全性。聚乳酸是可生物降解聚合物之一。它可通过乳酸的直接缩聚以及环状低聚物的聚合来制备。这两种聚合物均通过元素分析、红外光谱、X射线测试和分子量进行鉴定。它们在分子量和结晶度方面存在差异。针对聚乳酸作为直接压片辅助物质的用途，对粒度、水分含量、流动性以及直接压片参数进行了测定。结果表明，基于缩聚制备的聚乳酸是一种非常适合直接压片的辅助物质。
