Wohlrab W, Lasch J, Taube K M, Wozniak K D
Klinik und Poliklinik für Hautkrankheiten, Bereiches Medizin der Martin-Luther-Universität Halle-Wittenberg.
Pharmazie. 1989 May;44(5):333-5.
With the liposomal incorporated hydrocortisone a very much improved concentration-time profile was obtained in the different layers of human skin after topical application when compared with conventional hydrocortisone in the ointment. The increased hydrocortisone penetration into human skin correspond with the degree of blanching results by vasoconstriction test. Under in vivo conditions the influence of liposomal hydrocortisone on percutaneous resorption was investigated. In guinea pigs a decreased serum concentration and urinary excretion of hydrocortisone could be demonstrated. Thus, hydrocortisone-loaded liposomes, when applied topically, act as a selective drug delivery system, it can be provide increased therapeutic efficacy and, simultaneously, decreased unwanted systemic effects. The significance of liposomal incorporated attenuative and higher potent glucocorticoids in external therapy is discussed.
与软膏中的传统氢化可的松相比，局部应用后，脂质体包裹的氢化可的松在人皮肤不同层中获得了显著改善的浓度-时间曲线。氢化可的松渗透到人皮肤中的增加与血管收缩试验的变白结果程度相对应。在体内条件下，研究了脂质体氢化可的松对经皮吸收的影响。在豚鼠中，可以证明氢化可的松的血清浓度和尿排泄减少。因此，局部应用载有氢化可的松的脂质体可作为一种选择性药物递送系统，它可以提高治疗效果，同时减少不必要的全身作用。讨论了脂质体包裹的减效和高效糖皮质激素在外部治疗中的意义。
