Wallace S M, Falkenberg H M, Runikis J O, Stewart W D
Arch Dermatol. 1979 Apr;115(4):440-1.
Ointment containing 2.5% hydrocortisone was applied topically under occlusion to 84 subjects. Fifty-three percent of the population showed skin blanching in response to topical application of the steroid. To correlate vasoconstrictor response with drug level, hydrocortisone concentrations were determined fluorometrically in skin samples from 16 subjects in whom skin blanching was also assessed. The epidermal concentration of hydrocortisone was significantly greater in those subjects who exhibited blanching. Data suggest that a minimum epidermal reservoir of 200 micrograms of hydrocortisone per gram of lyophilized tissue is necessary to elicit a definite vasoconstrictor response.
将含有2.5%氢化可的松的软膏在封闭状态下局部应用于84名受试者。53%的受试者在局部应用该类固醇后出现皮肤变白。为了将血管收缩反应与药物水平相关联，对16名同时也评估了皮肤变白情况的受试者的皮肤样本进行荧光法测定氢化可的松浓度。在出现皮肤变白的受试者中，氢化可的松的表皮浓度显著更高。数据表明，每克冻干组织中至少有200微克氢化可的松的表皮储存量才能引发明确的血管收缩反应。
