Nasrollahzadeh Naser, Pioletti Dominique P
Laboratory of Biomechanical Orthopedics, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne (EPFL), Switzerland.
Laboratory of Biomechanical Orthopedics, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne (EPFL), Switzerland.
J Biomech. 2016 Nov 7;49(15):3749-3752. doi: 10.1016/j.jbiomech.2016.09.021. Epub 2016 Sep 21.
Permeability is an overarching mechanical parameter encompassing the effects of porosity, pore size, and interconnectivity of porous structures. This parameter directly influences transport of soluble particles and indirectly regulates fluid pressure and velocity in tissue engineering scaffolds. The permeability also contributes to the viscoelastic behavior of visco-porous material under loading through frictional drag mechanism. We propose a straightforward experimental method for permeability characterization of tissue engineering scaffolds. In the developed set-up a step-wise spacer was designed to facilitate measurement of the permeability under different compressive strains while maintaining similar experimental conditions during the successive measurements. As illustration of the method, we measured the permeability of scaffolds presenting different average pore sizes and subjected to different compression values. Results showed an exponential relationship between the permeability and the average pore size of the scaffolds. Furthermore, the trend of the permeability decrease with compressive strains was depending on pore sizes of the scaffolds. The permeability also appeared to play a role in relaxation behavior of the scaffolds.
渗透性是一个总体力学参数，涵盖了孔隙率、孔径和多孔结构连通性的影响。该参数直接影响可溶性颗粒的传输，并间接调节组织工程支架中的流体压力和流速。渗透性还通过摩擦阻力机制在加载下对粘弹性多孔材料的粘弹性行为起作用。我们提出了一种用于组织工程支架渗透性表征的简单实验方法。在所开发的装置中，设计了一个逐步间隔器，以便在不同压缩应变下测量渗透性，同时在连续测量期间保持相似的实验条件。作为该方法的示例，我们测量了具有不同平均孔径并承受不同压缩值的支架的渗透性。结果表明，渗透性与支架的平均孔径之间呈指数关系。此外，渗透性随压缩应变的降低趋势取决于支架的孔径。渗透性似乎也在支架的松弛行为中起作用。
