Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Institut für Medizinische Psychologie, Berlin, Germany.
Eur Urol. 2017 Feb;71(2):274-280. doi: 10.1016/j.eururo.2016.09.041. Epub 2016 Oct 6.
Literature on the health-related quality of life (HRQoL) for men with localized prostate cancer (PCa) on active surveillance (AS) shows a need for methodological guidance regarding HRQoL issues and how to address them.
The European School of Oncology Task Force (ESO TF) aimed to identify a core set of research questions and related measures to include in AS HRQoL studies.
DESIGN, SETTING, AND PARTICIPANTS: A modified Delphi study was used to reach consensus on AS HRQoL research topics and tools between 2014 and 2015. Data were collected by engaging a multidisciplinary team of 15 experts.
An open-ended questionnaire was used to collect information from ESO TF members regarding issues in AS HRQoL research. Then a structured questionnaire was used to collect ratings on the usefulness/importance of different AS HRQoL aspects. Items that ≥80% of ESO TF members rated as useful/important were retained. Items with a 50-80% rating were discussed to reach final agreement.
Six main research questions concerning the selection of outcome measures, measurement tools, and comparison groups were identified as relevant. The core set of measures identified were related to individual characteristics, psychological dimensions; decision-making-related issues, and physical functioning. The multidisciplinary expertise of ESO TF members was a significant asset, even if bringing different backgrounds to the discussion table represented a challenge.
HRQoL measures have to be sensitive to the specific needs of men on AS. The definition of HRQoL outcomes will enhance a broader understanding of the HRQoL of men on AS and sustain patient-centered medicine.
An international panel agreed on a set of health-related quality-of-life aspects to be assessed among men on active surveillance for prostate cancer. Valid relevant questionnaires were identified. The experts' indications lay a foundation for future research and clinical practice.
关于接受主动监测（AS）的局限性前列腺癌（PCa）男性的健康相关生活质量（HRQoL）的文献表明，需要针对 HRQoL 问题及其解决方法提供方法学指导。
欧洲肿瘤学会工作组（ESO TF）旨在确定一组核心研究问题和相关措施，以纳入 AS HRQoL 研究。
设计、地点和参与者：使用改良 Delphi 研究于 2014 年至 2015 年期间就 AS HRQoL 研究主题和工具达成共识。通过由 15 名多学科专家组成的团队收集数据。
使用开放式问卷收集 ESO TF 成员关于 AS HRQoL 研究中问题的信息。然后使用结构化问卷收集对不同 AS HRQoL 方面的有用性/重要性的评分。ESO TF 成员≥80%评分有用/重要的项目被保留。对评分在 50-80%的项目进行讨论，以达成最终协议。
确定了六个主要的研究问题，涉及选择结局测量、测量工具和对照组，认为这些问题与研究相关。确定的核心测量集与个体特征、心理维度、决策相关问题和身体功能有关。ESO TF 成员的多学科专业知识是一项重要资产，即使将不同背景带入讨论桌是一项挑战。
HRQoL 测量必须对接受 AS 的男性的特定需求敏感。HRQoL 结局的定义将增强对接受 AS 的男性 HRQoL 的更广泛理解，并支持以患者为中心的医学。
一个国际小组就主动监测前列腺癌男性的一系列健康相关生活质量方面达成一致。确定了有效的相关问卷。专家的意见为未来的研究和临床实践奠定了基础。
