[吉兰-巴雷多发性神经根炎的脑脊液参数。血脑屏障障碍和鞘内免疫球蛋白合成的重要性]
[Cerebrospinal fluid parameters in Guillain-Barré polyradiculitis. Importance of barrier disorder and intrathecal immunoglobulin synthesis].
作者信息
Papen R, Warecka K
机构信息
Neurologische Klinik, Medizinischen Universität zu Lübeck.
出版信息
Psychiatr Neurol Med Psychol (Leipz). 1989 Jun;41(6):334-43.
With routine CSF determination of 21 patients with GBS the BBB and the intrathecal IgG synthesis was investigated when calculated CSF/serum albumin ratio and CSF IgG-index respectively. Only in 2 of 21 patients (9.5%) an intrathecal IgG synthesis and in 14 of 21 patients (67%) a BBB damage was found. The BBB was considered as an important pathogenetic factor in GBS. A hypothesis for the development of the albumino-cytological dissociation is presented.
对21例吉兰-巴雷综合征（GBS）患者进行常规脑脊液检测，分别计算脑脊液/血清白蛋白比值和脑脊液IgG指数，以研究血脑屏障（BBB）和鞘内IgG合成情况。21例患者中仅2例（9.5%）发现鞘内IgG合成，14例（67%）发现血脑屏障损伤。血脑屏障被认为是吉兰-巴雷综合征的一个重要发病因素。本文提出了蛋白细胞分离现象发生发展的一种假说。
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