Dachsel R, Köppel C
Nervenklinik, BKH Friedrich Wolf Karl-Marx-Stadt.
Psychiatr Neurol Med Psychol (Leipz). 1989 Jul;41(7):420-5.
We carried out clinical and immunological follows-up to 21 patients suffering from multiple sclerosis, 16 of whom had been immunosuppressively treated. A remission in clinical way was possible to point out with 8 of 12 patients (66%) -average remission by 1 score acc. to the Bronx-Scale- and with these patients a local formation of immunoglobulin acc. to Reiber (1979) could be proven. With 40 to 60% of the patients pathological changes were found out by determining of routine parameters by means of liquor examinations (total number of cells, sediment, total protein, electrophoresis) in which the humoral values responded not so sensitively to immunosuppressive therapy than the cellular values. For the present, liquor- and immunodiagnostic is being considered as a solid part of diagnostic programm and therapy control with regard to patients suffering from multiple sclerosis.
我们对21例多发性硬化症患者进行了临床和免疫学随访，其中16例接受了免疫抑制治疗。12例患者中有8例（66%）出现了临床缓解——根据布朗克斯量表平均缓解1分——并且在这些患者中可以证明存在根据赖伯（1979年）的方法检测到的局部免疫球蛋白形成。通过脑脊液检查（细胞总数、沉淀物、总蛋白、电泳）测定常规参数，发现40%至60%的患者存在病理变化，其中体液值对免疫抑制治疗的反应不如细胞值敏感。目前，脑脊液和免疫诊断被认为是多发性硬化症患者诊断程序和治疗控制的重要组成部分。
