Tzika A A, Vigneron D B, Hricak H, Moseley M E, James T L, Kogan B A
Department of Radiology, University of California, San Francisco School of Medicine 94143.
Radiology. 1989 Sep;172(3):753-7. doi: 10.1148/radiology.172.3.2772183.
To develop phosphorus-31 magnetic resonance (MR) spectroscopy as an indicator of testicular viability, unilateral 720 degrees torsion of the spermatic cord was performed in 11 Copenhagen rats. In six of 11 rats, detorsion was done 1 hour later. The authors used special surface coils to obtain P-31 MR spectra (at 2 T) from both tests, then correlated MR findings with those from gross morphologic and histologic examination. In the normal testis, P-31 MR spectra had prominent phosphomonoester (PME) and adenosinetriphosphate (ATP) peaks. Testicular torsion dramatically reduced ATP to almost undetectable levels and significantly decreased the PME/Pi at 1 hour (1.18 +/- 0.22) in nine rats. In two rats, however, no spectral changes were present. Of the six rats in which detorsion was performed, three showed immediate regeneration of ATP and a normal PME/Pi (2.87 +/- 0.06) 3 hours later; testicles in the other three rats did not recover (PME/Pi = 0.72 +/- 0.01). Because gross morphologic observations and histologic findings prior to detorsion were unable to differentiate viable from nonviable tests, these preliminary data suggest P-31 MR spectroscopy may help clinicians diagnose testicular torsion and assess testicular viability.
为了将磷-31磁共振（MR）波谱学发展为睾丸活力的一项指标，对11只哥本哈根大鼠进行了精索单侧720度扭转。在11只大鼠中的6只里，1小时后进行了扭转复位。作者使用特殊表面线圈从双侧睾丸获取磷-31 MR波谱（在2T磁场下），然后将MR检查结果与大体形态学和组织学检查结果进行关联。在正常睾丸中，磷-31 MR波谱有明显的磷酸单酯（PME）和三磷酸腺苷（ATP）峰。睾丸扭转使ATP急剧降至几乎无法检测的水平，并在1小时时使9只大鼠的PME/Pi显著降低（1.18±0.22）。然而，有2只大鼠未出现波谱变化。在进行了扭转复位的6只大鼠中，3只在3小时后显示ATP立即再生且PME/Pi正常（2.87±0.06）；另外3只大鼠的睾丸未恢复（PME/Pi = 0.72±0.01）。由于扭转复位前的大体形态学观察和组织学发现无法区分存活与未存活的睾丸，这些初步数据表明磷-31 MR波谱学可能有助于临床医生诊断睾丸扭转并评估睾丸活力。
