大麦膳食纤维可降低模型动物的体脂并提高胰岛素敏感性。
barley dietary fibre reduces body fat and increases insulin sensitivity in model.
作者信息
Gao Chenfei, King Michael L, Fitzpatrick Zachary L, Wei Wenqian, King Jason F, Wang Mingming, Greenway Frank L, Finley John W, Burton Jeffrey H, Johnson William D, Keenan Michael J, Enright Frederick M, Martin Roy J, Zheng Jolene
机构信息
School of Nutrition and Food Sciences, College of Agriculture.
Department of Biological Science, College of Basic Science.
出版信息
J Funct Foods. 2015 Oct;18(A):564-574. doi: 10.1016/j.jff.2015.08.014. Epub 2015 Sep 14.
barley (PWB) is high in β-glucan with moderate content of resistant starch. PWB reduced intestinal fat deposition (IFD) in wild type , N2), and in or null mutants, and sustained a surrogate marker of lifespan, pharyngeal pumping rate (PPR), in N2, , or mutants. Hyperglycaemia (2% glucose) reversed or reduced the PWB effect on IFD in N2 or mutants with a sustained PPR. mRNA expression of , and were dose-dependently reduced in N2 or mutants, elevated in mutants with reduction in , and unchanged in mutants. mRNA expressions were increased by hyperglycaemia in N2 or mutants, while reduced in or mutants. The effects of PWB in the model appeared to be primarily mediated via , and . These data suggest that PWB and β-glucans may benefit hyperglycaemia-impaired lipid metabolism.
大麦（PWB）富含β-葡聚糖，抗性淀粉含量适中。PWB减少了野生型（N2）以及特定基因缺失突变体中的肠道脂肪沉积（IFD），并维持了N2、特定基因缺失突变体或其他突变体中寿命的替代指标——咽部抽吸率（PPR）。高血糖（2%葡萄糖）逆转或降低了PWB对N2或特定基因缺失突变体中IFD的影响，并维持了PPR。在N2或特定基因缺失突变体中，特定基因的mRNA表达呈剂量依赖性降低，在特定基因缺失且其他基因表达降低的突变体中升高，而在其他突变体中不变。在N2或特定基因缺失突变体中，高血糖会增加mRNA表达，而在其他突变体中则降低。PWB在该模型中的作用似乎主要通过特定基因介导。这些数据表明，PWB和β-葡聚糖可能有益于高血糖损害的脂质代谢。
Zotero 插件