van der Heijden Gydo, Kraakman Jasper, Biemolt Jasper, Ruijter Eelco, Orru Romano V A
Department of Chemistry and Pharmaceutical Sciences and Amsterdam Institute of Molecules, Medicines and Systems (AIMMS), Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands.
Org Biomol Chem. 2016 Oct 18;14(41):9716-9719. doi: 10.1039/c6ob01813k.
An efficient metal-free procedure for the formal α-carboxylation of primary alcohols has been developed. The method involves a one-pot oxidation/Passerini/hydrolysis sequence and provides access to α-hydroxy acids bearing a broad range of functional groups. A minor modification to the reaction conditions extends the range of accessible products to α-hydroxy esters.
已开发出一种高效的无金属方法用于伯醇的形式α-羧基化反应。该方法涉及一锅法氧化/帕瑟里尼反应/水解序列，可用于制备带有多种官能团的α-羟基酸。对反应条件进行微小调整后，可获得的产物范围扩展至α-羟基酯。
