Cebreiros I, Ordóñez A, García de Paredes M L, Vicente J, Martín G, González Barón M
Rev Clin Esp. 1989 Mar;184(5):247-8.
Today, excellent therapeutic results are obtained in Hodgkin's disease however, they may be obscured by the development of long term complications due to the treatment given including second neoplasias. Out of the total of 250 cases of Hodgkin's disease reviewed during 19 years we found 13 secondary neoplasias. All the patients received alkylating drugs and in 10, both chemo and radiotherapy were associated. The average interval of time was 48 months. Bronchopulmonary carcinomas and acute leukemias were the malignancies most often encountered.
如今,霍奇金淋巴瘤已取得了出色的治疗效果,然而,由于包括二次肿瘤形成在内的所给予治疗引发的长期并发症的出现,这些效果可能会被掩盖。在19年期间回顾的总共250例霍奇金淋巴瘤病例中,我们发现了13例二次肿瘤形成。所有患者均接受了烷化剂治疗,其中10例同时接受了化疗和放疗。平均时间间隔为48个月。支气管肺癌和急性白血病是最常出现的恶性肿瘤。