关于干性电荷在放射增敏作用中角色的猜想。
Conjecture on the role of dry charges in radiosensitization.
作者信息
Bakale G, Gregg E F
出版信息
Br J Cancer Suppl. 1978 Jun;3:24-8.
A model of cellular radiation damage that involves dry electrons and holes is proposed and the implications of this model to hypoxic radiosenstization are discussed. The transport and reaction properties of dry charges in the structured water surrounding polar biomolecules are considered and a solvation time of 600 picoseconds in this medium is derived. Pre-solvation charge migration, attachment and recombination and the relevance of these processes to sensitization are discussed. DNA damage by physico-chemical interactions with dry holes is proposed and is shown to be modified by oxygen and other electron affinic sensitizers.
提出了一种涉及自由电子和空穴的细胞辐射损伤模型，并讨论了该模型对缺氧放射增敏的影响。考虑了极性生物分子周围结构化水中自由电荷的传输和反应特性，并得出了该介质中600皮秒的溶剂化时间。讨论了预溶剂化电荷迁移、附着和复合以及这些过程与增敏的相关性。提出了通过与自由空穴的物理化学相互作用对DNA造成损伤的观点，并表明这种损伤会受到氧气和其他亲电子敏化剂的影响。
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