在实验性骨肉瘤中使用小剂量分次给药的米索硝唑。
Misonidazole with small dose fractions in an experimental osteosarcoma.
作者信息
van Putten L M, Smink T
出版信息
Br J Cancer Suppl. 1978 Jun;3:246-9.
Abstract
The mouse osteosarcoma C22LR was irradiated with a single X-ray dose of 1000 or 1500 rad (to prevent rapid growth) and then with fractionated doses of 300 or 600 rad each. Half the mice were given 0.8 mg/g of misonidazole 1 h before irradiation. Tumour growth delay was determined. The radiosensitizer did enhance the effect of small (300 rad) doses per fraction, as well as that of 600 rad doses.
摘要
将小鼠骨肉瘤C22LR用1000或1500拉德的单次X射线剂量进行照射（以防止快速生长），然后再给予每次300或600拉德的分次剂量照射。一半的小鼠在照射前1小时给予0.8毫克/克的米索硝唑。测定肿瘤生长延迟情况。放射增敏剂确实增强了每分次小剂量（300拉德）以及600拉德剂量的效果。
相似文献
1
Misonidazole with small dose fractions in an experimental osteosarcoma.在实验性骨肉瘤中使用小剂量分次给药的米索硝唑。
Br J Cancer Suppl. 1978 Jun;3:246-9.
2
The effect of misonidazole in combination with radiation dose fractionation.米索硝唑与放射剂量分割联合应用的效果。
Br J Cancer Suppl. 1978 Jun;3:255-8.
3
Sensitization of mouse tumours using fractionated X-irradiation.使用分次X射线照射使小鼠肿瘤致敏
Br J Cancer Suppl. 1978 Jun;3:259-63.
4
5
The effect of misonidazole in situ on the radiation response of selected tumor subpopoulations.丝裂霉素原位对选定肿瘤亚群辐射反应的影响。
Cancer Clin Trials. 1980 Summer;3(2):149-54.
6
7
The demonstration of in vivo misonidazole tumour toxicity using post radiation hypoxia.利用放疗后缺氧情况对米索硝唑的体内肿瘤毒性进行的论证。
Br J Cancer Suppl. 1978 Jun;3:228-31.
8
Studies in radiosensitizing effects of misonidazole and SR-2508 on C3H/He mouse mammary tumors.米索硝唑和SR-2508对C3H/He小鼠乳腺肿瘤的放射增敏作用研究。
Radiat Med. 1984 Jan-Mar;2(1):71-5.
9
Radiosensitization by misonidazole (Ro-07-0582) of fractionated X-rays in a murine tumour.米索硝唑（Ro-07-0582）对小鼠肿瘤分次X射线的放射增敏作用。
Br J Cancer Suppl. 1978 Jun;3:242-5.
10
The effects of misonidazole during continuous low dose rate irradiation.米索硝唑在连续低剂量率照射期间的作用。
Cancer Clin Trials. 1980 Fall;3(3):257-65.
Zotero 插件