水溶液中DNA的辐射损伤：放射增敏剂的作用
Radiation damage to DNA in aqueous solution: effects of radiosensitizers.
作者信息
Ward J F
出版信息
Br J Cancer Suppl. 1978 Jun;3:42-5.
Abstract
Systems are described for examining the molecular mode of action of anoxic radiosensitisers with DNA-OH radicals. Pulse radiolysis showed that NPPN reacts with these radicals even in the presence of 0.5 mM oxygen. Analysis of low molecular weight products liberated from DNA by irradiation showed that NPPN does not act in an oxygen-like way but that misonidazole does. Thus a molecular rationale exists for the use of combinations of radiosensitizers.
摘要
描述了用于研究缺氧放射增敏剂与DNA-OH自由基的分子作用模式的系统。脉冲辐解表明，即使在存在0.5 mM氧气的情况下，NPPN也能与这些自由基发生反应。对辐照后从DNA释放的低分子量产物的分析表明，NPPN的作用方式与氧气不同，而米索硝唑则与氧气的作用方式相同。因此，存在使用放射增敏剂组合的分子理论依据。
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Radiation damage to DNA in aqueous solution: effects of radiosensitizers.水溶液中DNA的辐射损伤：放射增敏剂的作用
Br J Cancer Suppl. 1978 Jun;3:42-5.
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本文引用的文献
1
Pulse radiolysis studies of the radiosensitizer Nor-pseudopelletierine-N-oxyl (NPPN). II. Reactions involving biological radicals.放射增敏剂去甲假石榴皮碱 -N- 氧基（NPPN）的脉冲辐解研究。II. 涉及生物自由基的反应。
Int J Radiat Biol Relat Stud Phys Chem Med. 1971;20(4):363-71. doi: 10.1080/09553007114551251.
2
Strand breaks, base release, and postirradiation changes in DNA gamma-irradiated in dilute O2-saturated aqueous solution.
Radiat Res. 1976 Jun;66(3):485-98.
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