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Polyfunctional radiosensitizers IV. The effect of contact time and temperature on sensitization of hypoxic Chinese hamster cells in vitro by bifunctional nitroxyl compounds.多功能放射增敏剂IV。接触时间和温度对双功能硝酰化合物体外致敏缺氧中国仓鼠细胞的影响。
Br J Cancer Suppl. 1978 Jun;3:73-9.
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Polyfunctional radiosensitizers. V. Sensitization of hypoxic Chinese hamster cells, V.79-753B, in vitro by a series of bifunctional nitroxyl compounds.多功能放射增敏剂。V. 一系列双功能硝酰化合物对体外培养的中国仓鼠V.79 - 753B缺氧细胞的增敏作用
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Polyfunctional radiosensitizers. VII. Radiosensitization by conformationally-restricted isomers of a nitroxyl biradical in vitro.多功能放射增敏剂。VII. 体外硝基氧双自由基构象受限异构体的放射增敏作用。
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Polyfunctional Radiosensitizers. VI. Dexamethasone inhibits shoulder modification by uncharged nitroxyl biradicals in mammalian cells irradiated in vitro.多功能放射增敏剂。VI. 地塞米松抑制体外照射的哺乳动物细胞中不带电荷的硝酰基双自由基对剂量存活曲线肩区的修饰作用。
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Polyfunctional radiosensitizers. I. Effects of a nitroxyl biradical on the survival of mammalian cells in vitro.多功能放射增敏剂。I. 一种硝酰基双自由基对体外培养的哺乳动物细胞存活的影响。
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Polyfunctional radiosensitizers III. Effect of the biradical (Ro-03-303) in combination with other radiosensitizers on the survival of hypoxic V-79 cells.多功能放射增敏剂III. 双自由基（Ro-03-303）与其他放射增敏剂联合使用对缺氧V-79细胞存活的影响。
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The effect of ploidy on the modification of the shoulder region of hypoxic cell-survival curves by the biradical, Ro.03-6061.多倍性对双自由基Ro.03 - 6061对缺氧细胞存活曲线肩部区域修饰的影响。
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本文引用的文献

1
X-ray inactivation of human cells in tissue culture under aerobic and extremely hypoxic conditions in the presence and absence of TMPN.在有氧和极度缺氧条件下，存在和不存在三甲基吡啶鎓硝酸盐（TMPN）时，组织培养中人类细胞的X射线失活。
Int J Radiat Biol Relat Stud Phys Chem Med. 1973 Sep;24(3):285-96. doi: 10.1080/09553007314551121.
2
Polyfunctional radiosensitizers. I. Effects of a nitroxyl biradical on the survival of mammalian cells in vitro.多功能放射增敏剂。I. 一种硝酰基双自由基对体外培养的哺乳动物细胞存活的影响。
Radiat Res. 1976 Jan;65(1):152-62.
3
Polyfunctional radiosensitizers III. Effect of the biradical (Ro-03-303) in combination with other radiosensitizers on the survival of hypoxic V-79 cells.多功能放射增敏剂III. 双自由基（Ro-03-303）与其他放射增敏剂联合使用对缺氧V-79细胞存活的影响。
Radiat Res. 1977 Mar;69(3):489-99.

多功能放射增敏剂IV。接触时间和温度对双功能硝酰化合物体外致敏缺氧中国仓鼠细胞的影响。

Polyfunctional radiosensitizers IV. The effect of contact time and temperature on sensitization of hypoxic Chinese hamster cells in vitro by bifunctional nitroxyl compounds.

作者信息

Millar B C, Fielden E M, Smithen C E

出版信息

Br J Cancer Suppl. 1978 Jun;3:73-9.

PMID:277261
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2149385/
Abstract

Three biradical nitroxyl compounds have been shown to modify the slope and shoulder region of the hypoxic cell survival curve of V79 cells to different degrees. The amount of sensitization produced by these compounds is dependent on the cell-drug contact time at both 20 degree and 37 degree C whereas sensitization by the monoradical nitroxyl, NPPN, is independent of these factors. The results suggest that biradicals may modify cellular biochemistry in such a way as to change the repair capacity of the cells. This could be responsible for changes in the shape of survival curves when cell-drug contact times are increased.

摘要

三种双自由基硝酰化合物已被证明能不同程度地改变V79细胞缺氧细胞存活曲线的斜率和肩部区域。这些化合物产生的敏化量在20摄氏度和37摄氏度下均取决于细胞与药物的接触时间，而单自由基硝酰NPPN的敏化作用则与这些因素无关。结果表明，双自由基可能以改变细胞修复能力的方式改变细胞生物化学。当细胞与药物的接触时间增加时，这可能是存活曲线形状变化的原因。