Killing AML: RIPK3 leads the way.
作者信息
Höckendorf Ulrike, Yabal Monica, Jost Philipp J
机构信息
a III. Medizinische Klinik für Hämatologie und Internistische Onkologie, Klinikum rechts der Isar, Technische Universität München , Munich , Germany.
出版信息
Cell Cycle. 2017 Jan 2;16(1):3-4. doi: 10.1080/15384101.2016.1232069. Epub 2016 Oct 11.
Abstract
摘要
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The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia.半胱天冬酶-8 抑制剂恩西地平与 SMAC 模拟物 birinapant 联合诱导坏死性凋亡并治疗急性髓系白血病。
Sci Transl Med. 2016 May 18;8(339):339ra69. doi: 10.1126/scitranslmed.aad3099.
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Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics.靶向 p38 或 MK2 可增强 Smac 模拟物的抗白血病活性。
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RIP3 induces apoptosis independent of pronecrotic kinase activity.RIP3诱导细胞凋亡，与坏死前激酶活性无关。
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