Markwardt F, Kaiser B, Nowak G
Institute of Pharmacology and Toxicology, Medical Academy Erfurt, GDR.
Thromb Res. 1989 Jun 1;54(5):377-88. doi: 10.1016/0049-3848(89)90208-9.
Recombinant desulfato hirudin (rH) was studied with regard to its effects on various models of thrombosis, its pharmacokinetic behaviour as well as its influence on primary haemostasis in rats. The pharmacological behaviour of rH proved to be similar to that of native hirudin. Depending on the different models of experimental thrombosis different dosages of rH were required to prevent thrombus formation. This corresponds to rH plasma concentrations of 0.5-1.5 micrograms/ml. Primary haemostasis is influenced only after excess dosages and plasma concentrations of 4 micrograms/ml and above.
对重组去硫酸水蛭素（rH）进行了研究，观察其对各种血栓形成模型的影响、药代动力学行为以及对大鼠初级止血的影响。结果表明，rH的药理行为与天然水蛭素相似。根据不同的实验性血栓形成模型，需要不同剂量的rH来预防血栓形成。这相当于rH血浆浓度为0.5 - 1.5微克/毫升。仅在过量给药且血浆浓度达到4微克/毫升及以上时，初级止血才会受到影响。
