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Not just leukemia: CMV may protect against lymphoma recurrence after allogeneic transplant.不仅是白血病：巨细胞病毒可能终究能预防异基因移植后淋巴瘤复发。
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[Cytomegalovirus infection after haploidentical stem cell transplantation may reduce relapse risk in leukemia].单倍体相合干细胞移植后巨细胞病毒感染可能降低白血病的复发风险
Zhonghua Nei Ke Za Zhi. 2016 Feb;55(2):107-10. doi: 10.3760/cma.j.issn.0578-1426.2016.02.008.
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[Cytomegalovirus specific cytotoxic T lymphocytes for treatment of refractory cytomegalovirus infection in patients following allogeneic hematopoietic stem cell transplantation].用于治疗异基因造血干细胞移植后患者难治性巨细胞病毒感染的巨细胞病毒特异性细胞毒性T淋巴细胞
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1
Cytomegalovirus infection is associated with rapid NK differentiation and reduced incidence of relapse in HLA matched sibling donor transplant patients.巨细胞病毒感染与 HLA 匹配的同胞供体移植患者中 NK 细胞的快速分化和降低复发率相关。
Clin Exp Immunol. 2022 Dec 31;210(3):283-294. doi: 10.1093/cei/uxac099.

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1
Early CMV-replication after allogeneic stem cell transplantation is associated with a reduced relapse risk in lymphoma.异基因干细胞移植后早期巨细胞病毒复制与淋巴瘤复发风险降低相关。
Leuk Lymphoma. 2017 Apr;58(4):822-833. doi: 10.1080/10428194.2016.1217524. Epub 2016 Aug 10.
2
Donor KIR B Genotype Improves Progression-Free Survival of Non-Hodgkin Lymphoma Patients Receiving Unrelated Donor Transplantation.供体KIR B基因型可改善接受无关供体移植的非霍奇金淋巴瘤患者的无进展生存期。
Biol Blood Marrow Transplant. 2016 Sep;22(9):1602-1607. doi: 10.1016/j.bbmt.2016.05.016. Epub 2016 May 21.
3
Latent cytomegalovirus infection enhances anti-tumour cytotoxicity through accumulation of NKG2C+ NK cells in healthy humans.潜伏性巨细胞病毒感染通过在健康人体内积累NKG2C+自然杀伤细胞增强抗肿瘤细胞毒性。
Clin Exp Immunol. 2016 Aug;185(2):239-51. doi: 10.1111/cei.12785.
4
Early cytomegalovirus reactivation remains associated with increased transplant-related mortality in the current era: a CIBMTR analysis.早期巨细胞病毒再激活在当前时代仍与移植相关死亡率增加相关：一项国际骨髓移植登记处（CIBMTR）的分析。
Blood. 2016 May 19;127(20):2427-38. doi: 10.1182/blood-2015-11-679639. Epub 2016 Feb 16.
5
Regulation of Adaptive NK Cells and CD8 T Cells by HLA-C Correlates with Allogeneic Hematopoietic Cell Transplantation and with Cytomegalovirus Reactivation.HLA-C对适应性自然杀伤细胞和CD8 T细胞的调控与异基因造血细胞移植及巨细胞病毒再激活相关。
J Immunol. 2015 Nov 1;195(9):4524-36. doi: 10.4049/jimmunol.1401990. Epub 2015 Sep 28.
6
CMV reactivation drives posttransplant T-cell reconstitution and results in defects in the underlying TCRβ repertoire.巨细胞病毒再激活驱动移植后T细胞重建，并导致潜在的TCRβ库出现缺陷。
Blood. 2015 Jun 18;125(25):3835-50. doi: 10.1182/blood-2015-03-631853. Epub 2015 Apr 7.
7
Mechanism of tumor remission by cytomegalovirus in a murine lymphoma model: evidence for involvement of virally induced cellular interleukin-15.巨细胞病毒在小鼠淋巴瘤模型中诱导肿瘤缓解的机制：病毒诱导的细胞白细胞介素-15参与的证据
Med Microbiol Immunol. 2015 Jun;204(3):355-66. doi: 10.1007/s00430-015-0408-z. Epub 2015 Mar 25.
8
Early CMV replication and subsequent chronic GVHD have a significant anti-leukemic effect after allogeneic HSCT in acute myeloid leukemia.在急性髓系白血病的异基因造血干细胞移植后，早期巨细胞病毒复制及随后的慢性移植物抗宿主病具有显著的抗白血病作用。
Ann Hematol. 2015 Feb;94(2):275-82. doi: 10.1007/s00277-014-2190-1. Epub 2014 Aug 20.
9
Sensitivity of hematological malignancies to graft-versus-host effects: an EBMT megafile analysis.血液系统恶性肿瘤对移植物抗宿主效应的敏感性：EBMT 海量分析。
Leukemia. 2014 Nov;28(11):2235-40. doi: 10.1038/leu.2014.145. Epub 2014 Apr 30.
10
Impact of cytomegalovirus replication and cytomegalovirus serostatus on the outcome of patients with B cell lymphoma after allogeneic stem cell transplantation.巨细胞病毒复制及巨细胞病毒血清学状态对异基因造血干细胞移植后B细胞淋巴瘤患者预后的影响
Biol Blood Marrow Transplant. 2014 Jun;20(6):885-90. doi: 10.1016/j.bbmt.2014.02.015. Epub 2014 Feb 28.

Not just leukemia: CMV may protect against lymphoma recurrence after allogeneic transplant.

作者信息

Peled Jonathan U, Jenq Robert R

机构信息

a Adult Bone Marrow Transplantation Service, Memorial Sloan Kettering Cancer Center , New York , NY , USA.

出版信息

Leuk Lymphoma. 2017 Apr;58(4):759-761. doi: 10.1080/10428194.2016.1239265. Epub 2016 Oct 12.

DOI:10.1080/10428194.2016.1239265
PMID:27733072
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5354121/
Abstract
摘要