Trejo L J, Rand M N, Cicerone C M
Navy Personnel Research and Development Center, San Diego, CA 92152.
Vision Res. 1989;29(3):303-7. doi: 10.1016/0042-6989(89)90078-3.
We measured the pupillary light reflex (PLR) in 5 pigmented, Long Evans rats (under urethan sedation) in three conditions: direct stimulation, consensual stimulation, and a control condition designed to measure the effects of stray light. The average constriction (maximal amplitude) produced by a ganzfeld stimulus delivering 1.6 log quanta absorbed per rod per sec for a duration of 3 sec was measured to be 0.78 +/- 0.07 mm for the direct PLR, 0.67 +/- 0.06 mm for the consensual PLR, and 0.07 +/- 0.029 mm for the control condition. We corrected the consensual measurement for each rat by subtracting the value of the control (stray-light induced) constriction. A comparison of the corrected consensual constriction to the direct constriction showed that, on average, the consensual constriction attained an amplitude of 78% of the direct constriction. Our findings contradict claims that the consensual pupillary light reflex is absent in rodents. Although our results are in agreement with findings showing bilateral projections of the retina to the pretectum (which subserves the pupillary light reflex) in the rat, the consensual-to-direct ratio we report is higher than might be expected from anatomical estimates of the overall proportion of uncrossed to crossed optic fibers in the rat.
我们在5只色素沉着的Long Evans大鼠（在氨基甲酸乙酯麻醉下）身上，于三种条件下测量了瞳孔对光反射（PLR）：直接刺激、间接刺激，以及一种旨在测量杂散光影响的对照条件。对于直接PLR，由全视野刺激产生的平均收缩（最大幅度），该刺激每秒每根视杆吸收1.6对数量子，持续3秒，测量值为0.78±0.07毫米；对于间接PLR，测量值为0.67±0.06毫米；对于对照条件，测量值为0.07±0.029毫米。我们通过减去对照（杂散光诱导）收缩的值，对每只大鼠的间接测量值进行了校正。将校正后的间接收缩与直接收缩进行比较，结果显示，平均而言，间接收缩幅度达到直接收缩幅度的78%。我们的研究结果与啮齿动物不存在间接瞳孔对光反射的说法相矛盾。尽管我们的结果与显示大鼠视网膜向中脑顶盖前区（其参与瞳孔对光反射）的双侧投射的研究结果一致，但我们报告的间接与直接比例高于根据大鼠未交叉与交叉视神经纤维的总体比例的解剖学估计可能预期的值。
