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本文引用的文献

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The difference between Asian and Western in the effect of LDL-C lowering therapy on coronary atherosclerotic plaque: a meta-analysis report.亚洲人与西方人在低密度脂蛋白胆固醇（LDL-C）降低治疗对冠状动脉粥样硬化斑块影响方面的差异：一项荟萃分析报告
BMC Cardiovasc Disord. 2015 Feb 14;15:6. doi: 10.1186/1471-2261-15-6.
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2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines.2013年美国心脏病学会/美国心脏协会成人降低动脉粥样硬化性心血管风险的血胆固醇治疗指南：美国心脏病学会/美国心脏协会实践指南工作组报告
Circulation. 2014 Jun 24;129(25 Suppl 2):S1-45. doi: 10.1161/01.cir.0000437738.63853.7a. Epub 2013 Nov 12.
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Lack of association between SLCO1B1 polymorphisms and clinical myalgia following rosuvastatin therapy.SLCO1B1 多态性与瑞舒伐他汀治疗后临床肌痛无关。
Am Heart J. 2013 Jun;165(6):1008-14. doi: 10.1016/j.ahj.2013.01.025. Epub 2013 Apr 10.
4
Do the lipid responses to rosuvastatin and atorvastatin differ between Chinese and Caucasians? Comparison of the DISCOVERY-Hong Kong study with other DISCOVERY studies.中国人群与高加索人群对瑞舒伐他汀和阿托伐他汀的脂质反应是否存在差异？DISCOVERY-香港研究与其他DISCOVERY研究的比较。
Int J Cardiol. 2013 Oct 3;168(3):3071-3. doi: 10.1016/j.ijcard.2013.04.091. Epub 2013 May 1.
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Guidelines for Secondary Prevention of Myocardial Infarction (JCS 2011).心肌梗死二级预防指南（日本循环学会2011年版）
Circ J. 2013;77(1):231-48. doi: 10.1253/circj.cj-66-0053. Epub 2012 Nov 17.
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Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial.他汀类药物所致低密度脂蛋白胆固醇降低的遗传决定因素：他汀类药物在预防中的应用理由：一项评估瑞舒伐他汀的干预试验（JUPITER试验）
Circ Cardiovasc Genet. 2012 Apr 1;5(2):257-64. doi: 10.1161/CIRCGENETICS.111.961144. Epub 2012 Feb 13.
7
Comparison of the pharmacokinetics of pitavastatin by formulation and ethnic group: an open-label, single-dose, two-way crossover pharmacokinetic study in healthy Caucasian and Japanese men.制剂和种族因素对匹伐他汀药代动力学的影响比较：一项在健康白种人和日本男性中开展的开放性、单剂量、两周期交叉药代动力学研究。
Clin Drug Investig. 2011 Oct 1;31(10):735-43. doi: 10.2165/11592480-000000000-00000.
8
ESC/EAS Guidelines for the management of dyslipidaemias: the Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS).ESC/EAS 血脂异常管理指南：欧洲心脏病学会（ESC）和欧洲动脉粥样硬化学会（EAS）血脂异常管理工作组
Eur Heart J. 2011 Jul;32(14):1769-818. doi: 10.1093/eurheartj/ehr158. Epub 2011 Jun 28.
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Race differences: modeling the pharmacodynamics of rosuvastatin in Western and Asian hypercholesterolemia patients.种族差异：在西方和亚洲高胆固醇血症患者中模拟瑞舒伐他汀的药效动力学。
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10
Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials.更强化降低 LDL 胆固醇的疗效和安全性：来自 26 项随机试验中 170000 名参与者数据的荟萃分析。
Lancet. 2010 Nov 13;376(9753):1670-81. doi: 10.1016/S0140-6736(10)61350-5. Epub 2010 Nov 8.

他汀类药物降胆固醇作用的种族差异。

Racial Differences in the Cholesterol-Lowering Effect of Statin.

作者信息

Naito Ryo, Miyauchi Katsumi, Daida Hiroyuki

机构信息

Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine.

出版信息

J Atheroscler Thromb. 2017 Jan 1;24(1):19-25. doi: 10.5551/jat.RV16004. Epub 2016 Oct 12.

DOI:10.5551/jat.RV16004
PMID:27733728
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5225129/
Abstract

Statin treatment to reduce low-density lipoprotein cholesterol (LDL-C) is associated with the prevention of cardiovascular events in Western patients. Similar results have been reported in studies conducted in Japan. However, the dose of statins and the degree of LDL-C reduction achieved with statins are different between Asian and Western patients. In addition, there are limited data regarding racial differences in response to statins. In this review, racial differences between Asians and Westerners in response to statins are described.

摘要

使用他汀类药物治疗以降低低密度脂蛋白胆固醇（LDL-C）与预防西方患者心血管事件相关。在日本进行的研究也报告了类似结果。然而，亚洲患者和西方患者使用他汀类药物的剂量以及他汀类药物实现的LDL-C降低程度有所不同。此外，关于他汀类药物反应的种族差异的数据有限。在本综述中，描述了亚洲人和西方人对他汀类药物反应的种族差异。