Perlman Sharon, Lotan Dani, Dekel Benjamin, Kivilevitch Zvi, Hazan Yinon, Achiron Reuven, Gilboa Yinon
Prenatal Diagnostic Unit, Department of Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer, Israel.
Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Prenat Diagn. 2016 Nov;36(11):1075-1080. doi: 10.1002/pd.4938.
To create nomograms of fetal renal compensatory growth in cases of unilateral renal agenesis (URA).
A retrospective study of fetuses with isolated URA diagnosed prenatally, and confirmed postnatal was performed.
Seventy-four fetuses with isolated solitary kidney were included in the study. A total of 134 measurements of the kidney's length were performed. Ninety five of them were studied longitudinally (2-6 measurements each). The raw values of the compensatory kidney demonstrated a significant correlation with gestational age (Pearson correlation coefficient 0.901, p < 0.001). A quadratic/cubic regression curve, both, described best this relationship, -26.400 + 3.004GA, -0.026GA (r = 0.819). The Z score between the mean predicted compensatory kidney's length, per week of gestation, and the mean predicted values of normal kidney length as previously published in the literature, progressively increased during pregnancy (cubic r = 0.946 and 0.260).
Cases of URA show a unique growth pattern of the single kidney from second trimester to term. Postnatal renal function is dependent on adequate intra-uterine compensatory growth; the presented nomograms provide insight into renal prognosis and add paramount information to the multidisciplinary prenatal counseling of the future parents. © 2016 John Wiley & Sons, Ltd.
创建单侧肾缺如（URA）病例中胎儿肾代偿性生长的列线图。
对产前诊断为孤立性URA且产后确诊的胎儿进行回顾性研究。
本研究纳入了74例孤立性单肾胎儿。共进行了134次肾脏长度测量。其中95次为纵向研究（每次2 - 6次测量）。代偿性肾脏的原始值与孕周呈显著相关性（Pearson相关系数0.901，p < 0.001）。二次/三次回归曲线均能最好地描述这种关系，即 -26.400 + 3.004GA - 0.026GA（r = 0.819）。与文献中先前公布的正常肾脏长度的平均预测值相比，妊娠各周代偿性肾脏长度的平均预测值之间的Z评分在孕期逐渐增加（三次r = 0.946和0.260）。
URA病例显示单肾从孕中期到足月有独特的生长模式。产后肾功能取决于宫内充分的代偿性生长；所呈现的列线图有助于了解肾脏预后，并为未来父母的多学科产前咨询提供至关重要的信息。© 2016 John Wiley & Sons, Ltd.
