Gruev I, Kiroĭcheva M, Nikolov K, Bozhkov B, Baleva M
Vutr Boles. 1989;28(3):73-7.
The urine concentration of secretory immunoglobulin A was studied in 58 healthy persons (26 women and 32 men) and in 55 patients (44 women and 11 men) with chronic recurrent pyelonephritis before the beginning of the antibacterial treatment. An immunoenzyme method on a solid phase was used (ELISA). In 21 patients a lowered urine secretory immunoglobulin A level (IgA) was found, in 19 patients it was elevated and in 15 patients it was in normal ranges. In the group of patients with an elevated secretory IgA level the antibacterial treatment was successful in 89.5% of the patients while in the group of patients with a lowered secretory IgA level the treatment was successful only in 61.9% of the patients. In 12 patients the secretory IgA level was examined after the treatment and in 72.7% of them it was changed--in 38.2% of the patients the level was lowered and in 34.5% of the patients it was elevated. The local immune response of the organism against infections is discussed.
在58名健康人（26名女性和32名男性）以及55名慢性复发性肾盂肾炎患者（44名女性和11名男性）接受抗菌治疗前，对其尿液中分泌型免疫球蛋白A的浓度进行了研究。采用固相免疫酶法（ELISA）。在21名患者中发现尿液分泌型免疫球蛋白A水平（IgA）降低，19名患者升高，15名患者处于正常范围。在分泌型IgA水平升高的患者组中，89.5%的患者抗菌治疗成功，而在分泌型IgA水平降低的患者组中，治疗仅在61.9%的患者中成功。在12名患者治疗后检测了分泌型IgA水平，其中72.7%的患者水平发生了变化——38.2%的患者水平降低，34.5%的患者水平升高。文中讨论了机体对感染的局部免疫反应。
