Stárka Luboslav
Vnitr Lek. 2016 Fall;62(9 Suppl 3):127-130.
Subnormal levels of testosterone are frequently found in men of higher age category. Hypogonadal men have lower life expectancy than men with full androgenization and cardiovascular disease, obesity or diabetes is often associated with hypotestosteronemia. Low testosterone level is risk factor for these diseases. However, until now it is not clear whether testosterone deficiency is a cause or consequence of atherosclerosis or metabolic syndrome. A handful of symptoms and metabolic risk markers in hypogonadal men can be ameliorated by testosterone supplementation. Testosterone treatment increased sexual activity and well-being and had a moderate benefit with respect to depressive symptoms but no significant benefit to vitality. Testosterone has a beneficial effect on cardiovascular risk factors, but there is not clear whether it reduces mortality.Key words: civilization diseases - late onset hypogonadism - morbidity - mortality - testosterone - testosterone supplementation.
在年龄较大的男性中，经常发现睾酮水平低于正常水平。性腺功能减退的男性预期寿命低于雄激素化正常的男性，且心血管疾病、肥胖或糖尿病常与低睾酮血症相关。低睾酮水平是这些疾病的危险因素。然而，迄今为止尚不清楚睾酮缺乏是动脉粥样硬化或代谢综合征的原因还是结果。补充睾酮可改善性腺功能减退男性的一些症状和代谢风险指标。睾酮治疗可提高性活动能力和幸福感，对抑郁症状有一定益处，但对活力无显著益处。睾酮对心血管危险因素有有益作用，但尚不清楚其是否能降低死亡率。关键词：文明病 - 迟发性性腺功能减退 - 发病率 - 死亡率 - 睾酮 - 睾酮补充剂
