Zhou Yuanyuan, Tao Xianghua, Yao Qiyi, Zhao Yulei, Li Yanzhong
Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, P. R. China.
Chemistry. 2016 Dec 12;22(50):17936-17939. doi: 10.1002/chem.201603798. Epub 2016 Nov 9.
The transition-metal-free insertion of isolated alkynes into carbon-carbon σ-bonds of unstrained cyclic β-dicarbonyl compounds has been reported. These tandem reactions offer an efficient synthesis of medium-sized ring or fused-ring compounds through ring expansion. The methodology has the potential to be widely used throughout organic synthesis due to the easily accessible starting materials and mild reaction conditions.
据报道，孤立的炔烃可在无过渡金属的条件下插入到无张力环状β-二羰基化合物的碳-碳σ键中。这些串联反应通过环扩张提供了一种高效合成中环或稠环化合物的方法。由于起始原料易于获得且反应条件温和，该方法有在整个有机合成中广泛应用的潜力。
