Dorta G, Siebenmann R, Fröhli P, Freytag P, Koelz H R
Medizinische Klinik, Stadtspital Triemli, Zürich.
Z Gastroenterol. 1989 Jul;27(7):388-90.
We report on a patient who became jaundiced during treatment with clozapine (Leponex). Histologically, cholestatic hepatitis with single-cell necroses of hepatocytes and infiltration of the portal zones with eosinophilic granulocytes were found. The patient recovered after discontinuation of clozapine, and liver function tests returned to normal within 4 weeks. This adverse effect of clozapine suggests that this "atypical" tricyclic neuroleptic resembles the phenothiazines both with regard to therapeutic spectrum and side effects.
我们报告了1例在使用氯氮平（Leponex）治疗期间出现黄疸的患者。组织学检查发现胆汁淤积性肝炎伴肝细胞单细胞坏死以及门静脉区嗜酸性粒细胞浸润。停用氯氮平后患者康复，肝功能检查在4周内恢复正常。氯氮平的这一不良反应表明，这种“非典型”三环类抗精神病药物在治疗谱和副作用方面与吩噻嗪类药物相似。
