Erdoğan İlkay, Bilginer Yelda, Düzova Ali, Beşbaş Nesrin
Division of Pediatric Cardiology, Department of Pediatrics, Başkent University Faculty of Medicine, Ankara, Turkey.
Turk J Pediatr. 2015 Nov-Dec;57(6):587-591.
Tacrolimus is a potent immunosuppressive agent widely used after organ transplantation. In this present study we present eight patients who complained of palpitation after kidney transplantation. Eight out of 31 patients who received tacrolimus after kidney transplantation suffered from tachycardia. Resting electrocardiography, 24 hours Holter monitorization, echocardiography were performed, and serum levels of cardiac troponin T, creatine kinase, CKMB, brain natriuretic peptide and tacrolimus were measured. The median time to palpitation after kidney transplantation was 30 days in seven patients, and one patient complained of palpitation five years after transplantation. Cardiovascular assessment revealed sinus tachycardia in all patients. Beta-blocker was instituted in five patients. After two months all patients were asymptomatic and their pulse rates were within normal limits. Transient sinus tachycardia is a frequent adverse event during tacrolimus therapy in children and young adults, at therapeutic levels. Patients may benefit from beta-blockers.
他克莫司是一种强效免疫抑制剂，广泛应用于器官移植后。在本研究中，我们报告了8例肾移植后出现心悸的患者。31例肾移植后接受他克莫司治疗的患者中有8例出现心动过速。进行了静息心电图、24小时动态心电图监测、超声心动图检查，并测定了血清心肌肌钙蛋白T、肌酸激酶、肌酸激酶同工酶、脑钠肽和他克莫司水平。7例患者肾移植后出现心悸的中位时间为30天，1例患者在移植后5年出现心悸。心血管评估显示所有患者均为窦性心动过速。5例患者使用了β受体阻滞剂。两个月后，所有患者均无症状，脉搏率在正常范围内。在儿童和年轻人中，治疗剂量的他克莫司治疗期间，短暂性窦性心动过速是一种常见的不良事件。患者可能会从β受体阻滞剂中获益。
