发育中的大鼠小脑——III. 甲状腺状态异常和营养不良对神经节苷脂的影响。

Developing rat cerebellum--III. Effects of abnormal thyroid states and undernutrition on gangliosides.

作者信息

Vitiello F, Clos J, Di Benedetta C, Gombos G

机构信息

Istituto di Fisiologia Umana, Facoltà di Medicina e Chirurgia, Bari, Italy.

出版信息

Int J Dev Neurosci. 1989;7(4):335-41. doi: 10.1016/0736-5748(89)90055-5.

DOI:10.1016/0736-5748(89)90055-5

PMID:2773669

Abstract

Alteration of rat postnatal cerebellar development produced by undernutrition, thyroxine treatment and thyroid deficiency also involves ganglioside deposition. The distribution of the different ganglioside types is apparently unaffected but quantitative alterations are present that reflect the reduction of cell number and cell process surface in the adult, and either acceleration or slowing down or reduction of cell formation and maturation occurring during cerebellar development in the three experimental situations.

摘要

营养不良、甲状腺素治疗和甲状腺功能减退所导致的大鼠出生后小脑发育改变也涉及神经节苷脂沉积。不同类型神经节苷脂的分布显然未受影响，但存在定量改变，这些改变反映了成年期细胞数量和细胞突起表面的减少，以及在三种实验情况下小脑发育过程中细胞形成、成熟的加速、减慢或减少。