Demirkaya Sevcan Karakoç, Alyanak Behiye
Dr. Demirkaya, MD, Assistant Professor, Child and Adolescent Psychiatry, Adnan Menderes University Faculty of Medicine, Aydin, Turkey. Dr. Alyanak, MD, Professor, Child and Adolescent Psychiatry, Istanbul University Istanbul Faculty of Medicine, Istanbul, Turkey.
Psychopharmacol Bull. 2016 Mar 1;46(1):73-76.
Obsessive compulsive disorder (OCD) is characterized by recurrent, unwanted thoughts (obsessions) and/or repetitive behaviors (compulsions). Although selective serotonin reuptake inhibitors are widely used to treat OCD, only half of the patients respond well. Several potentiation strategies including off-label use of antipsychotics (mostly risperidone, quetiapine) have been tried. Ziprasidone is an atypical antipsychotic with the best affinity ratio of 5 HT and 5HT receptors. There is a limited data on ziprasidone in pediatric groups. The case described in the following is an example for the augmentation with ziprasidone to treatment refractory OCD.
强迫症（OCD）的特征是反复出现的、不必要的想法（强迫观念）和/或重复行为（强迫行为）。尽管选择性5-羟色胺再摄取抑制剂被广泛用于治疗强迫症，但只有一半的患者反应良好。已经尝试了几种增效策略，包括非标签使用抗精神病药物（主要是利培酮、喹硫平）。齐拉西酮是一种非典型抗精神病药物，对5-羟色胺（5-HT）和5-HT受体具有最佳亲和力。关于齐拉西酮在儿科群体中的数据有限。以下所述病例是使用齐拉西酮增强治疗难治性强迫症的一个例子。
