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含汞藏药的化学物种、微观形态及X射线衍射指纹图谱分析

Chemical Species, Micromorphology, and XRD Fingerprint Analysis of Tibetan Medicine Containing Mercury.

作者信息

Li Cen, Yang Hongxia, Du Yuzhi, Xiao Yuancan, Wang Zhang, Ladan Duojie, Bi Hongtao, Wei Lixin

机构信息

Pharmacology and Safety Evaluation Key Laboratory of Tibetan Medicine in Qinghai Province, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining, Qinghai 810008, China; Key Laboratory of Tibetan Medicine Research, Chinese Academy of Sciences, Xining, Qinghai 810008, China.

Tibetan Traditional Medical College, Lhasa, Tibet 850000, China.

出版信息

Bioinorg Chem Appl. 2016;2016:7010519. doi: 10.1155/2016/7010519. Epub 2016 Sep 21.

DOI:10.1155/2016/7010519
PMID:27738409
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5050389/
Abstract

() is one of the famous drugs containing mercury in Tibetan medicine. However, little is known about the chemical substance basis of its pharmacodynamics and the intrinsic link of different samples sources so far. Given this, energy dispersive spectrometry of X-ray (EDX), scanning electron microscopy (SEM), atomic force microscopy (AFM), and powder X-ray diffraction (XRD) were used to assay the elements, micromorphology, and phase composition of nine samples from different regions, respectively; the XRD fingerprint features of were analyzed by multivariate statistical analysis. EDX result shows that contains Hg, S, O, Fe, Al, Cu, and other elements. SEM and AFM observations suggest that is a kind of ancient nanodrug. Its particles are mainly in the range of 100-800 nm, which commonly further aggregate into 1-30 m loosely amorphous particles. XRD test shows that -HgS, S, and -HgS are its main phase compositions. XRD fingerprint analysis indicates that the similarity degrees of nine samples are very high, and the results of multivariate statistical analysis are broadly consistent with sample sources. The present research has revealed the physicochemical characteristics of , and it would play a positive role in interpreting this mysterious Tibetan drug.

摘要

（）是藏药中著名的含汞药物之一。然而，迄今为止，对其药效学的化学物质基础以及不同样品来源的内在联系知之甚少。鉴于此，分别采用X射线能量色散谱（EDX）、扫描电子显微镜（SEM）、原子力显微镜（AFM）和粉末X射线衍射（XRD）对来自不同地区的9个样品的元素、微观形态和相组成进行了测定；通过多元统计分析对（）的XRD指纹特征进行了分析。EDX结果表明（）含有汞、硫、氧、铁、铝、铜等元素。SEM和AFM观察表明（）是一种古老的纳米药物。其颗粒主要在100 - 800纳米范围内，通常进一步聚集成1 - 30微米的松散无定形颗粒。XRD测试表明，α-HgS、S和β-HgS是其主要相组成。XRD指纹分析表明9个样品的相似度非常高，多元统计分析结果与样品来源大致一致。本研究揭示了（）的理化特性，对解读这种神秘的藏药将起到积极作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf7d/5050389/fc61349a5971/BCA2016-7010519.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf7d/5050389/063691849f8e/BCA2016-7010519.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf7d/5050389/b69f6203ae47/BCA2016-7010519.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf7d/5050389/81d078afb4b0/BCA2016-7010519.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf7d/5050389/d03bd1200670/BCA2016-7010519.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf7d/5050389/a87f7eacc545/BCA2016-7010519.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf7d/5050389/d3d9b160342c/BCA2016-7010519.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf7d/5050389/32b4c624e201/BCA2016-7010519.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf7d/5050389/fc61349a5971/BCA2016-7010519.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf7d/5050389/063691849f8e/BCA2016-7010519.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf7d/5050389/b69f6203ae47/BCA2016-7010519.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf7d/5050389/81d078afb4b0/BCA2016-7010519.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf7d/5050389/d03bd1200670/BCA2016-7010519.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf7d/5050389/a87f7eacc545/BCA2016-7010519.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf7d/5050389/d3d9b160342c/BCA2016-7010519.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf7d/5050389/32b4c624e201/BCA2016-7010519.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf7d/5050389/fc61349a5971/BCA2016-7010519.008.jpg

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