la Torre Argelia Rosillo-de, Rocha Luisa, Salgado-Ceballos Hermelinda, García Casillas Perla E, Luna-Barcenas Gabriel
Calz. Tenorios 235. Col. Granjas Coapa, 14330 at the Department of Pharmacobiology, Center of Research and Advanced Studies, P.O. Box: 22026, Mexico City,. Mexico.
Mini Rev Med Chem. 2017;17(3):237-246. doi: 10.2174/1389557516666161013105000.
Pharmacoresistant epilepsy is a disabling neuronal disorder with harmful consequences that impact patient's quality of life. Although psychiatric comorbidities are frequently present in patients with epilepsy, they are more common in those patients with pharmacoresistant epilepsy. Despite medical advances, the current existing therapeutic strategies for pharmacoresistant seizure control are not available for all patients and/or present disadvantages. Moreover, the conventional drug therapies for psychiatric comorbidities have several adverse effects. Therefore, in this field, nanotechnology arises as a novel tool for transporting drugs to the brain under pathological conditions with high efficiency and low side effects. </p> <p> Objective: Present an overview of nanotechnology as a novel, efficient and enhanced therapeutic strategy for controlling pharmacoresistant epilepsy and its associated psychiatric comorbidities. </p> <p> Conclusion: Nanotechnology emerges as a powerful tool for the control and/or treatment of pharmacoresistant epilepsy and its comorbidities in a more efficient and safer way than conventional treatments.
药物难治性癫痫是一种致残性神经元疾病，会产生有害后果，影响患者的生活质量。虽然癫痫患者常伴有精神疾病共病，但在药物难治性癫痫患者中更为常见。尽管医学取得了进步，但目前现有的控制药物难治性癫痫发作的治疗策略并非对所有患者都适用，和/或存在缺点。此外，用于治疗精神疾病共病的传统药物疗法有 several 种不良反应。因此，在这一领域，纳米技术作为一种新型工具出现，可在病理条件下高效、低副作用地将药物输送到大脑。</p> <p>目的：概述纳米技术作为一种新型、高效且增强的治疗策略，用于控制药物难治性癫痫及其相关精神疾病共病。</p> <p>结论：与传统治疗方法相比，纳米技术成为一种更高效、更安全地控制和/或治疗药物难治性癫痫及其共病的有力工具。
原文中“several”翻译为“几种”，这里保留英文是因为不太明确其确切含义。
