植入式药物递送系统给药的水凝胶中明胶对盐酸毛果芸香碱泪液量的持续影响
The Sustained Effects on Tear Volume of Pilocarpine Hydrochloride in Gelatin by Hydrogel Administered by An Implant-mediated Drug Delivery System.
作者信息
Cha Seunghee, Kim Hong-Kyun, Kho Hong-Seop, Park Young-Seok
机构信息
Oral and Maxillofacial Diagnostic Sciences, College of Dentistry, University of Florida, Gainesville, United States.
Department of Oral Anatomy, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Korea.
出版信息
Curr Drug Deliv. 2017;14(4):581-586. doi: 10.2174/1567201813666161013150648.
BACKGROUND
Pilocarpine hydrochloride is commonly prescribed to patients with dry mouth and eye using a frequent dosing schedule. The aim of this study was to evaluate the sustained effects of this highly soluble drug carried by a gelatin hydrogel, which was administered by an implant mediated drug delivery system (IMDDS).
METHODS
The IMDDS was installed in a total of 24 rabbits. After complete healing, pilocarpine hydrochloride was administered as 30 mg as raw powder (Group 1; n = 8), 30 mg in gelatin hydrogel (Group 2; n = 8), and 60 mg in gelatin hydrogel (Group 3; n = 8). The effects were evaluated by tear volume measured using the Schirmer tear test for 2 weeks after administration.
RESULTS
All 3 groups showed an increase in tear volume from the initial measurement at 1 hour. Group 1 exhibited this increase for 24 hours, while Groups 2 and 3 sustained this increase for 5 days and 7.5 days, respectively.
CONCLUSION
When provided in gelatin hydrogel, highly water-soluble pilocarpine hydrochloride administered through IMDDS resulted in sustained effects with increased tear volume in normal rabbits.
背景
盐酸毛果芸香碱常用于口干和眼干患者，给药频率较高。本研究的目的是评估由明胶水凝胶携带的这种高溶性药物的持续作用，该药物通过植入介导药物递送系统（IMDDS）给药。
方法
总共24只兔子安装了IMDDS。完全愈合后，分别以30mg原料药粉末（第1组；n = 8）、30mg明胶水凝胶（第2组；n = 8）和60mg明胶水凝胶（第3组；n = 8）的形式给予盐酸毛果芸香碱。给药后2周，使用泪液分泌试验测量泪液量来评估效果。
结果
所有3组在给药后1小时的初始测量中泪液量均增加。第1组在24小时内出现这种增加，而第2组和第3组分别在5天和7.5天内持续增加。
结论
通过IMDDS给予的高水溶性盐酸毛果芸香碱在明胶水凝胶中时，可使正常兔子的泪液量增加并产生持续作用。
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