Hydraulic Machinery Research Inst., School of Mechanical Engineering, College of Engineering, University of Tehran, North Kargar St., Tehran, Iran.
Curr Drug Deliv. 2014;11(1):123-31. doi: 10.2174/156720181101140212165729.
Systemic drug delivery is the most prevalent form of the drug administration; but it is not possible to extend this approach to all of diseases. In the traditional approaches of drug delivery, the drug spreads through whole of body and this could cause severe side effects in the healthy parts. In addition, in some parts of our body like the eye, ear and brain, there are biological barriers against drug penetration which made drug delivery to these organs as a challenging work. Micropumps are one of the MEMS based devices with great capabilities in controlled drug administration. The most prevalent application of micropumps in drug delivery is known as continuous subcutaneous insulin infusion (CSII) for diabetic patients; but our study showed that there are some other ongoing investigations to extend application of micropumps in new treatment methods for some incurred diseases.
全身给药是药物给药最常见的形式;但不可能将这种方法应用于所有疾病。在传统的药物输送方法中，药物会扩散到全身，这可能会对健康部位造成严重的副作用。此外，在我们身体的某些部位，如眼睛、耳朵和大脑，存在着阻止药物穿透的生物屏障，使得向这些器官输送药物成为一项具有挑战性的工作。微泵是基于 MEMS 的设备之一，在药物控制给药方面具有强大的功能。微泵在药物输送中的最常见应用是为糖尿病患者进行连续皮下胰岛素输注(CSII);但我们的研究表明，还有一些其他正在进行的研究，将微泵的应用扩展到一些已发生疾病的新治疗方法中。
