Gonzalez A, Krassikoff N, Gilbert-Barness E F
Department of Pathology, University of Wisconsin, Madison 53795.
Am J Med Genet. 1989 Apr;32(4):457-60. doi: 10.1002/ajmg.1320320404.
Despite improved prenatal care, infants of diabetic mothers (IDM) have an increased risk of congenital malformations. We report on an IDM with multiple congenital anomalies consistent with the polyasplenia complex with associated mesocardia and renal agenesis. The morphologic characteristics of these malformations are discussed. Special emphasis is given to the polyasplenia complex as an example of midline developmental field defect. The importance of maternal levels of hemoglobin A1c in relation to congenital malformations is addressed.
尽管产前护理有所改善，但糖尿病母亲的婴儿（IDM）发生先天性畸形的风险仍会增加。我们报告了一例患有多种先天性异常的IDM，这些异常符合多脾综合征，并伴有中位心和肾缺如。文中讨论了这些畸形的形态学特征。特别强调将多脾综合征作为中线发育场缺陷的一个例子。文中还探讨了母亲糖化血红蛋白水平与先天性畸形的关系。
