Kaufman Joel D, Spalt Elizabeth W, Curl Cynthia L, Hajat Anjum, Jones Miranda R, Kim Sun-Young, Vedal Sverre, Szpiro Adam A, Gassett Amanda, Sheppard Lianne, Daviglus Martha L, Adar Sara D
Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA; Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USA; Department of Medicine, University of Washington, Seattle, WA, USA.
Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USA.
Glob Heart. 2016 Sep;11(3):343-352. doi: 10.1016/j.gheart.2016.07.004.
The MESA Air (Multi-Ethnic Study of Atherosclerosis and Air Pollution) leveraged the platform of the MESA cohort into a prospective longitudinal study of relationships between air pollution and cardiovascular health. MESA Air researchers developed fine-scale, state-of-the-art air pollution exposure models for the MESA Air communities, creating individual exposure estimates for each participant. These models combine cohort-specific exposure monitoring, existing monitoring systems, and an extensive database of geographic and meteorological information. Together with extensive phenotyping in MESA-and adding participants and health measurements to the cohort-MESA Air investigated environmental exposures on a wide range of outcomes. Advances by the MESA Air team included not only a new approach to exposure modeling, but also biostatistical advances in addressing exposure measurement error and temporal confounding. The MESA Air study advanced our understanding of the impact of air pollutants on cardiovascular disease and provided a research platform for advances in environmental epidemiology.
动脉粥样硬化与空气污染多族裔研究（MESA Air）利用MESA队列平台，开展了一项关于空气污染与心血管健康关系的前瞻性纵向研究。MESA Air研究人员为MESA Air社区开发了精细的、最先进的空气污染暴露模型，为每位参与者创建了个体暴露估计值。这些模型结合了特定队列的暴露监测、现有监测系统以及广泛的地理和气象信息数据库。MESA Air研究团队在MESA进行了广泛的表型分析，并向队列中增加了参与者和健康测量指标，从而研究了多种环境暴露对一系列结果的影响。MESA Air团队的进展不仅包括一种新的暴露建模方法，还包括在解决暴露测量误差和时间混杂方面的生物统计学进展。MESA Air研究增进了我们对空气污染物对心血管疾病影响的理解，并为环境流行病学的进展提供了一个研究平台。
