用于难治性哮喘急性加重的胰高血糖素。

Glucagon for refractory asthma exacerbation.

作者信息

Cavallari Jillian M, Jawaro Tara S, Awad Nadia I, Bridgeman Patrick J

机构信息

Department of Pharmacy, Robert Wood Johnson University Hospital, New Brunswick, NJ; Department of Pharmacy Practice and Administration, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ.

Department of Pharmacy, Robert Wood Johnson University Hospital, New Brunswick, NJ.

出版信息

Am J Emerg Med. 2017 Jan;35(1):144-145. doi: 10.1016/j.ajem.2016.09.063. Epub 2016 Sep 30.

DOI:10.1016/j.ajem.2016.09.063

PMID:27742523

Abstract

Glucagon, a hormone secreted by pancreatic alpha cells, causes bronchial smooth muscle relaxation by activating the synthesis of cyclic adenosine monophosphate. It was studied in the 1980s and 1990s as a treatment option for the management of asthma but has since not been evaluated. Data to support its use are limited, but it may serve as a last-line agent for refractory asthma exacerbation. Here we describe 4 cases in which intravenous glucagon was used to manage severe, refractory asthma exacerbation in the emergency department.

摘要

胰高血糖素是一种由胰腺α细胞分泌的激素，它通过激活环磷酸腺苷的合成来引起支气管平滑肌舒张。在20世纪80年代和90年代，它作为哮喘管理的一种治疗选择进行了研究，但此后未再进行评估。支持其使用的数据有限，但它可能作为难治性哮喘加重的最后一线药物。在此，我们描述4例在急诊科使用静脉注射胰高血糖素治疗严重难治性哮喘加重的病例。