First Department of Obstetrics and Gynecology, Centre of Postgraduate Medical Education, Warsaw, Poland.
Department of Biochemistry and Clinical Chemistry, Department of Pharmacogenomics, Medical University of Warsaw, Warsaw, Poland.
Fertil Steril. 2016 Dec;106(7):1787-1792. doi: 10.1016/j.fertnstert.2016.09.007. Epub 2016 Oct 12.
To evaluate the influence of 25-hydroxyvitamin D and transforming growth factor β3 (TGF-β3) serum concentrations, weight, and family history on the risk of developing uterine fibroids.
Retrospective cohort study.
University hospital.
PATIENT(S): A total of 188 women, including patients admitted for uterine fibroid surgery (n = 105) as the study group and healthy women of similar age (n = 83) as controls.
INTERVENTION(S): Medical history and completion of specially designed questionnaire, transvaginal or transabdominal genital ultrasound scan, blood sampling, and measurement of vitamin D and TGF-β3 serum concentrations.
MAIN OUTCOME MEASURE(S): Evaluation of the impact of family history, vitamin D, and TGF-β3 serum concentrations on the risk of developing uterine fibroids.
RESULT(S): Mean 25-hydroxyvitamin D serum concentrations were 21.9 ± 8.9 ng/mL and 26.7 ± 11.9 ng/mL in patients with uterine fibroids and controls, respectively. The difference was statistically significant. The TGF-β3 serum concentrations in the fibroid-positive group ranged from 1.20 to 436.15 pg/mL (half the patients had concentrations >16.25 pg/mL). Concentrations in the control group ranged from 0.96 to 49.08 pg/mL (half the women had concentrations of >11.80 pg/mL). The differences were statistically significant. Higher body mass index (BMI) and positive family history were also found to be among the risk factors for uterine fibroids.
CONCLUSION(S): Our study confirmed higher BMI, positive family history, and lower vitamin D and higher TGF-β3 serum concentrations as risk factors for uterine fibroids.
评估 25-羟维生素 D 和转化生长因子β3（TGF-β3）血清浓度、体重和家族史对子宫肌瘤发病风险的影响。
回顾性队列研究。
大学医院。
共纳入 188 名女性患者，包括因子宫肌瘤接受手术的患者（n=105）作为研究组和年龄相匹配的健康女性（n=83）作为对照组。
详细病史询问和专门设计的问卷调查、经阴道或经腹妇科超声检查、采血以及维生素 D 和 TGF-β3 血清浓度测定。
评估家族史、维生素 D 和 TGF-β3 血清浓度对子宫肌瘤发病风险的影响。
子宫肌瘤患者和对照组的平均 25-羟维生素 D 血清浓度分别为 21.9±8.9 ng/ml 和 26.7±11.9 ng/ml，差异有统计学意义。阳性子宫肌瘤患者 TGF-β3 血清浓度范围为 1.20436.15 pg/ml（一半患者浓度>16.25 pg/ml），对照组为 0.9649.08 pg/ml（一半患者浓度>11.80 pg/ml），差异有统计学意义。较高的体重指数（BMI）和阳性家族史也是子宫肌瘤的危险因素。
本研究证实较高的 BMI、阳性家族史、较低的维生素 D 和较高的 TGF-β3 血清浓度是子宫肌瘤的危险因素。
