Rowley P T
Department of Medicine, University of Rochester School of Medicine, New York 14642.
Ann N Y Acad Sci. 1989;565:48-52. doi: 10.1111/j.1749-6632.1989.tb24149.x.
Prenatal diagnoses for sickle cell disease in the United States and Canada numbered at least 1065 through the end of 1987. The 272 prenatal diagnoses in the United States in 1987 constituted only about 4.1% of the estimated pregnancies at risk. The termination rate for diagnosed fetuses was 39% for sickle cell anemia and 23% for hemoglobin SC disease. Prenatal hemoglobinopathy screening programs should not be judged solely on the number of terminations for affected fetuses. Other benefits are reassurance for couples shown to have an unaffected fetus and, for couples shown to have an affected fetus, preparation for the birth of a child requiring special care and information relevant to future childbearing.
到1987年底，美国和加拿大对镰状细胞病的产前诊断至少有1065例。1987年美国的272例产前诊断仅占估计有风险妊娠的约4.1%。镰状细胞贫血诊断胎儿的终止妊娠率为39%，血红蛋白SC病为23%。产前血红蛋白病筛查项目不应仅根据受影响胎儿的终止妊娠数量来评判。其他益处包括让被证明胎儿未受影响的夫妇安心，以及让被证明胎儿受影响的夫妇为需要特殊护理的孩子的出生做好准备，并提供与未来生育相关的信息。
