杏仁核中央核中5-羟色胺释放的体感调节是通过背缝核中的促肾上腺皮质激素释放因子和γ-氨基丁酸介导的。
Somatosensory regulation of serotonin release in the central nucleus of the amygdala is mediated via corticotropin releasing factor and gamma-aminobutyric acid in the dorsal raphe nucleus.
作者信息
Tokunaga Ryota, Shimoju Rie, Shibata Hideshi, Kurosawa Mieko
机构信息
Center for Medical Science, International University of Health and Welfare, 2600-1 Kitakanemaru, Otawara, Tochigi, 324-8501, Japan.
Division of Physical Therapy, Graduate School of Health and Welfare Sciences, International University of Health and Welfare, Otawara, Tochigi, 324-8501, Japan.
出版信息
J Physiol Sci. 2017 Nov;67(6):689-698. doi: 10.1007/s12576-016-0498-4. Epub 2016 Oct 15.
Noxious cutaneous stimulation increases, whereas innocuous cutaneous stimulation decreases serotonin (5-HT) release in the central nucleus of the amygdala (CeA) in anesthetized rats. In the present study, we investigated the contribution of corticotropin releasing factor (CRF) receptors and gamma-aminobutyric acid (GABA) receptors in the dorsal raphe nucleus (DRN) to those responses. Release of 5-HT in the CeA was monitored by microdialysis before and after 10-min stimulation by pinching or stroking. Increased 5-HT release in the CeA in response to pinching was abolished by CRF receptor antagonism in the DRN. Decreased 5-HT release in the CeA in response to stroking was abolished by either CRF receptor antagonism or GABA receptor antagonism in the DRN. These results suggest that opposite responses of 5-HT release in the CeA to noxious versus innocuous stimulation of the skin are due to separate contributions of CRF, CRF and GABA receptors in the DRN.
在麻醉大鼠中，有害的皮肤刺激会增加，而无害的皮肤刺激会减少杏仁核中央核（CeA）中5-羟色胺（5-HT）的释放。在本研究中，我们调查了背缝核（DRN）中的促肾上腺皮质激素释放因子（CRF）受体和γ-氨基丁酸（GABA）受体对这些反应的作用。在通过捏或抚摸进行10分钟刺激之前和之后，通过微透析监测CeA中5-HT的释放。DRN中的CRF受体拮抗作用消除了因捏而导致的CeA中5-HT释放增加。DRN中的CRF受体拮抗作用或GABA受体拮抗作用均消除了因抚摸而导致的CeA中5-HT释放减少。这些结果表明，CeA中5-HT释放对皮肤有害与无害刺激的相反反应是由于DRN中CRF、CRF和GABA受体的不同作用。
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