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Somatosensory regulation of serotonin release in the central nucleus of the amygdala is mediated via corticotropin releasing factor and gamma-aminobutyric acid in the dorsal raphe nucleus.杏仁核中央核中5-羟色胺释放的体感调节是通过背缝核中的促肾上腺皮质激素释放因子和γ-氨基丁酸介导的。
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Inhibition of serotonin outflow by nociceptin/orphaninFQ in dorsal raphe nucleus slices from normal and stressed rats: Role of corticotropin releasing factor.孤啡肽/痛敏肽对正常和应激大鼠中缝背核切片5-羟色胺外流的抑制作用：促肾上腺皮质激素释放因子的作用
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Serotonin release in the central nucleus of the amygdala in response to noxious and innocuous cutaneous stimulation in anesthetized rats.在麻醉大鼠中，对有害和无害的皮肤刺激的反应中，杏仁中央核中的血清素释放。
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Corticotropin-releasing factor 1 and 2 receptors in the dorsal raphé differentially affect serotonin release in the nucleus accumbens.中缝背核中的促肾上腺皮质激素释放因子1和2受体对伏隔核中5-羟色胺的释放有不同影响。
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Microinjection of urocortin 2 into the dorsal raphe nucleus activates serotonergic neurons and increases extracellular serotonin in the basolateral amygdala.将尿皮质素2微量注射到中缝背核会激活5-羟色胺能神经元，并增加基底外侧杏仁核中的细胞外5-羟色胺。
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Chronic amphetamine treatment enhances corticotropin-releasing factor-induced serotonin release in the amygdala.慢性安非他命处理增强了杏仁核中促肾上腺皮质释放因子诱导的血清素释放。
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Alteration of serotonin release response in the central nucleus of the amygdala to noxious and non-noxious mechanical stimulation in a neuropathic pain model rat.在神经病理性疼痛模型大鼠中，中央杏仁核中 5-羟色胺释放反应对有害和非有害机械刺激的改变。
J Physiol Sci. 2024 Mar 12;74(1):17. doi: 10.1186/s12576-024-00910-x.

本文引用的文献

1
Serotonin release in the central nucleus of the amygdala in response to noxious and innocuous cutaneous stimulation in anesthetized rats.在麻醉大鼠中，对有害和无害的皮肤刺激的反应中，杏仁中央核中的血清素释放。
J Physiol Sci. 2016 Jul;66(4):307-14. doi: 10.1007/s12576-015-0426-z. Epub 2015 Dec 14.
2
Serotonergic responses to stress are enhanced in the central amygdala and inhibited in the ventral hippocampus during amphetamine withdrawal.在苯丙胺戒断期间，中央杏仁核中对压力的5-羟色胺能反应增强，而腹侧海马体中的反应受到抑制。
Eur J Neurosci. 2014 Dec;40(11):3684-92. doi: 10.1111/ejn.12735. Epub 2014 Sep 19.
3
Massage therapy research review.按摩疗法研究综述。
Complement Ther Clin Pract. 2014 Nov;20(4):224-9. doi: 10.1016/j.ctcp.2014.07.002. Epub 2014 Aug 1.
4
Corticotropin-releasing factor-related peptides, serotonergic systems, and emotional behavior.促肾上腺皮质释放因子相关肽、5-羟色胺能系统与情绪行为。
Front Neurosci. 2013 Sep 20;7:169. doi: 10.3389/fnins.2013.00169.
5
Serotonergic innervation of the amygdala: targets, receptors, and implications for stress and anxiety.杏仁核的血清素能神经支配：靶标、受体及对应应激和焦虑的影响。
Histochem Cell Biol. 2013 Jun;139(6):785-813. doi: 10.1007/s00418-013-1081-1. Epub 2013 Mar 15.
6
Chronic amphetamine treatment enhances corticotropin-releasing factor-induced serotonin release in the amygdala.慢性安非他命处理增强了杏仁核中促肾上腺皮质释放因子诱导的血清素释放。
Eur J Pharmacol. 2010 Oct 10;644(1-3):80-7. doi: 10.1016/j.ejphar.2010.07.008. Epub 2010 Jul 23.
7
The influence of negative emotions on pain: behavioral effects and neural mechanisms.负面情绪对疼痛的影响：行为效应与神经机制。
Neuroimage. 2009 Sep;47(3):987-94. doi: 10.1016/j.neuroimage.2009.05.059. Epub 2009 May 28.
8
Corticotropin-releasing factor increases GABA synaptic activity and induces inward current in 5-hydroxytryptamine dorsal raphe neurons.促肾上腺皮质激素释放因子增加γ-氨基丁酸（GABA）突触活性，并在5-羟色胺中缝背核神经元中诱导内向电流。
J Neurosci. 2008 Nov 26;28(48):12927-37. doi: 10.1523/JNEUROSCI.2887-08.2008.
9
Restraint stress increases serotonin release in the central nucleus of the amygdala via activation of corticotropin-releasing factor receptors.束缚应激通过激活促肾上腺皮质激素释放因子受体增加杏仁核中央核中血清素的释放。
Brain Res Bull. 2008 Jul 30;76(5):493-8. doi: 10.1016/j.brainresbull.2008.02.011. Epub 2008 Mar 4.
10
Corticotropin-releasing factor 1 and 2 receptors in the dorsal raphé differentially affect serotonin release in the nucleus accumbens.中缝背核中的促肾上腺皮质激素释放因子1和2受体对伏隔核中5-羟色胺的释放有不同影响。
Eur J Pharmacol. 2008 Jan 14;578(2-3):185-93. doi: 10.1016/j.ejphar.2007.09.024. Epub 2007 Oct 2.

杏仁核中央核中5-羟色胺释放的体感调节是通过背缝核中的促肾上腺皮质激素释放因子和γ-氨基丁酸介导的。

Somatosensory regulation of serotonin release in the central nucleus of the amygdala is mediated via corticotropin releasing factor and gamma-aminobutyric acid in the dorsal raphe nucleus.

作者信息

Tokunaga Ryota, Shimoju Rie, Shibata Hideshi, Kurosawa Mieko

机构信息

Center for Medical Science, International University of Health and Welfare, 2600-1 Kitakanemaru, Otawara, Tochigi, 324-8501, Japan.

Division of Physical Therapy, Graduate School of Health and Welfare Sciences, International University of Health and Welfare, Otawara, Tochigi, 324-8501, Japan.

出版信息

J Physiol Sci. 2017 Nov;67(6):689-698. doi: 10.1007/s12576-016-0498-4. Epub 2016 Oct 15.

DOI:10.1007/s12576-016-0498-4
PMID:27744641
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10718013/
Abstract

Noxious cutaneous stimulation increases, whereas innocuous cutaneous stimulation decreases serotonin (5-HT) release in the central nucleus of the amygdala (CeA) in anesthetized rats. In the present study, we investigated the contribution of corticotropin releasing factor (CRF) receptors and gamma-aminobutyric acid (GABA) receptors in the dorsal raphe nucleus (DRN) to those responses. Release of 5-HT in the CeA was monitored by microdialysis before and after 10-min stimulation by pinching or stroking. Increased 5-HT release in the CeA in response to pinching was abolished by CRF receptor antagonism in the DRN. Decreased 5-HT release in the CeA in response to stroking was abolished by either CRF receptor antagonism or GABA receptor antagonism in the DRN. These results suggest that opposite responses of 5-HT release in the CeA to noxious versus innocuous stimulation of the skin are due to separate contributions of CRF, CRF and GABA receptors in the DRN.

摘要

在麻醉大鼠中，有害的皮肤刺激会增加，而无害的皮肤刺激会减少杏仁核中央核（CeA）中5-羟色胺（5-HT）的释放。在本研究中，我们调查了背缝核（DRN）中的促肾上腺皮质激素释放因子（CRF）受体和γ-氨基丁酸（GABA）受体对这些反应的作用。在通过捏或抚摸进行10分钟刺激之前和之后，通过微透析监测CeA中5-HT的释放。DRN中的CRF受体拮抗作用消除了因捏而导致的CeA中5-HT释放增加。DRN中的CRF受体拮抗作用或GABA受体拮抗作用均消除了因抚摸而导致的CeA中5-HT释放减少。这些结果表明，CeA中5-HT释放对皮肤有害与无害刺激的相反反应是由于DRN中CRF、CRF和GABA受体的不同作用。