Tapia Rico Gonzalo, Townsend Amanda R, Klevansky Myron, Price Timothy J
a Department of Medical Oncology , The Queen Elizabeth Hospital , Adelaide , SA , Australia.
b University of Adelaide , Adelaide , SA , Australia.
Expert Rev Anticancer Ther. 2016 Dec;16(12):1219-1225. doi: 10.1080/14737140.2016.1249858. Epub 2016 Oct 31.
Surgical resection of liver metastases from colorectal and neuroendocrine tumours has become a standard of care for resectable patients with isolated hepatic disease and good performance status, leading to extended survival in a carefully selected subgroup of these patients. However, the role of hepatic surgery in gastric and oesophageal liver metastases is controversial and not clearly defined. Areas covered:a systematic electronic literature search was performed to select the most representative evidence regarding hepatectomies in liver metastases from these two tumours. PubMed, Medline, Embase Ovid and Google Scholar databases were scanned for articles written in English and published in peer-reviewed journals between 1994 and May 2016. Expert commentary: Given the shortage of randomised studies and the limited number of patients in many of the studies discussed here, the evidence base for the use of hepatectomies in these settings is not strong. Thus, while the data for resections of gastric liver metastases may in particular seem encouraging, the results should be interpreted with caution.
对于患有孤立性肝脏疾病且身体状况良好的可切除患者，手术切除结直肠癌和神经内分泌肿瘤的肝转移灶已成为一种标准治疗方法，这使得经过精心挑选的该类患者亚组的生存期得以延长。然而，肝脏手术在胃癌和食管癌肝转移中的作用存在争议且尚无明确定义。涵盖领域：进行了系统的电子文献检索，以选择关于这两种肿瘤肝转移灶肝切除术的最具代表性的证据。扫描了PubMed、Medline、Embase Ovid和谷歌学术数据库，查找1994年至2016年5月期间发表在同行评审期刊上的英文文章。专家评论：鉴于随机研究的缺乏以及此处讨论的许多研究中患者数量有限，在这些情况下使用肝切除术的证据基础并不充分。因此，虽然胃癌肝转移灶切除术的数据可能尤其令人鼓舞，但对结果的解读应谨慎。
