Benis Damien, David Olivier, Piallat Brigitte, Kibleur Astrid, Goetz Laurent, Bhattacharjee Manik, Fraix Valérie, Seigneuret Eric, Krack Paul, Chabardès Stéphan, Bastin Julien
Université Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, Grenoble Cedex 9, France; Inserm, U1216, Grenoble Cedex 9, France.
Université Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, Grenoble Cedex 9, France; Inserm, U1216, Grenoble Cedex 9, France; CHU Grenoble Alpes, Department of Neurology, Grenoble Cedex 9, France.
Cortex. 2016 Nov;84:111-123. doi: 10.1016/j.cortex.2016.09.006. Epub 2016 Sep 21.
The subthalamic nucleus (STN) plays a critical role during action inhibition, perhaps by acting like a fast brake on the motor system when inappropriate responses have to be rapidly suppressed. However, the mechanisms involving the STN during motor inhibition are still unclear, particularly because of a relative lack of single-cell responses reported in this structure in humans. In this study, we used extracellular microelectrode recordings during deep brain stimulation surgery in patients with Parkinson's disease (PD) to study STN neurophysiological correlates of inhibitory control during a stop signal task. We found two neuronal subpopulations responding either during motor execution (GO units) or during motor inhibition (STOP units). GO units fired selectively before patients' motor responses whereas STOP units fired selectively when patients successfully withheld their move at a latency preceding the duration of the inhibition process. These results provide electrophysiological evidence for the hypothesized role of the STN in current models of response inhibition.
丘脑底核（STN）在动作抑制过程中起着关键作用，可能是通过在必须迅速抑制不适当反应时，像对运动系统施加快速制动一样发挥作用。然而，运动抑制过程中涉及STN的机制仍不清楚，特别是因为在人类该结构中报道的单细胞反应相对较少。在本研究中，我们在帕金森病（PD）患者的脑深部刺激手术期间使用细胞外微电极记录，以研究停止信号任务期间抑制控制的STN神经生理相关性。我们发现了两个神经元亚群，分别在运动执行期间（GO单位）或运动抑制期间（STOP单位）做出反应。GO单位在患者运动反应之前选择性放电，而STOP单位在患者成功抑制动作时，在抑制过程持续时间之前的潜伏期选择性放电。这些结果为STN在当前反应抑制模型中的假设作用提供了电生理证据。
