• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Do p38 mitogen-activated protein kinase inhibitors have a future for the treatment of cardiovascular disease?

作者信息

Kompa Andrew R

机构信息

Centre of Cardiovascular Research and Education in Therapeutics, Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.

出版信息

J Thorac Dis. 2016 Sep;8(9):E1068-E1071. doi: 10.21037/jtd.2016.07.94.

DOI:10.21037/jtd.2016.07.94
PMID:27747066
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5059343/
Abstract
摘要

相似文献

1
Do p38 mitogen-activated protein kinase inhibitors have a future for the treatment of cardiovascular disease?p38丝裂原活化蛋白激酶抑制剂在心血管疾病治疗中有前景吗？
J Thorac Dis. 2016 Sep;8(9):E1068-E1071. doi: 10.21037/jtd.2016.07.94.
2
Insulin activates p38 mitogen-activated protein (MAP) kinase via a MAP kinase kinase (MKK) 3/MKK 6 pathway in vascular smooth muscle cells.胰岛素通过丝裂原活化蛋白激酶（MAP）激酶激酶（MKK）3/MKK 6途径激活血管平滑肌细胞中的p38丝裂原活化蛋白激酶。
Eur J Clin Invest. 2000 Aug;30(8):668-77. doi: 10.1046/j.1365-2362.2000.00671.x.
3
Stimulation of MAPK cascades by insulin and osmotic shock: lack of an involvement of p38 mitogen-activated protein kinase in glucose transport in 3T3-L1 adipocytes.胰岛素和渗透压休克对丝裂原活化蛋白激酶（MAPK）级联反应的刺激：p38丝裂原活化蛋白激酶不参与3T3-L1脂肪细胞的葡萄糖转运
Diabetes. 2000 Nov;49(11):1783-93. doi: 10.2337/diabetes.49.11.1783.
4
p38 mitogen-activated protein kinase inhibitors for the treatment of chronic cardiovascular disease.
Curr Opin Investig Drugs. 2003 Sep;4(9):1059-64.
5
Pancreatic stellate cell activation by ethanol and acetaldehyde: is it mediated by the mitogen-activated protein kinase signaling pathway?乙醇和乙醛对胰腺星状细胞的激活作用：是否由丝裂原活化蛋白激酶信号通路介导？
Pancreas. 2003 Aug;27(2):150-60. doi: 10.1097/00006676-200308000-00008.
6
Signaling pathways leading to the induction of ornithine decarboxylase: opposite effects of p44/42 mitogen-activated protein kinase (MAPK) and p38 MAPK inhibitors.导致鸟氨酸脱羧酶诱导的信号通路：p44/42丝裂原活化蛋白激酶（MAPK）和p38 MAPK抑制剂的相反作用。
Biochem Pharmacol. 2001 Jan 1;61(1):25-32. doi: 10.1016/s0006-2952(00)00515-3.
7
FR167653 diminishes infarct size in a murine model of myocardial ischemia-reperfusion injury.FR167653可减小心肌缺血再灌注损伤小鼠模型中的梗死面积。
J Thorac Cardiovasc Surg. 2004 Oct;128(4):588-94. doi: 10.1016/j.jtcvs.2004.02.007.
8
Inhibition of the p38 mitogen-activated protein kinase by SB 203580 blocks PMA-induced Mr 92,000 type IV collagenase secretion and in vitro invasion.SB 203580对p38丝裂原活化蛋白激酶的抑制作用可阻断佛波酯诱导的92,000分子量IV型胶原酶分泌及体外侵袭。
Cancer Res. 1998 Mar 15;58(6):1135-9.
9
Sequence-dependent potentiation of paclitaxel-mediated apoptosis in human leukemia cells by inhibitors of the mitogen-activated protein kinase kinase/mitogen-activated protein kinase pathway.丝裂原活化蛋白激酶激酶/丝裂原活化蛋白激酶途径抑制剂对人白血病细胞中紫杉醇介导的细胞凋亡的序列依赖性增强作用。
Mol Pharmacol. 2001 Jul;60(1):143-54. doi: 10.1124/mol.60.1.143.
10
The p38 mitogen-activated protein kinase is required for IL-12-induced IFN-gamma expression.IL-12诱导的IFN-γ表达需要p38丝裂原活化蛋白激酶。
J Immunol. 2000 Aug 1;165(3):1374-80. doi: 10.4049/jimmunol.165.3.1374.

引用本文的文献

1
Dual-action kinase inhibitors influence p38α MAP kinase dephosphorylation.双效激酶抑制剂影响p38α丝裂原活化蛋白激酶的去磷酸化。
Proc Natl Acad Sci U S A. 2025 Jan 7;122(1):e2415150122. doi: 10.1073/pnas.2415150122. Epub 2024 Dec 31.
2
Dual-Action Kinase Inhibitors Influence p38α MAP Kinase Dephosphorylation.双效激酶抑制剂影响p38α丝裂原活化蛋白激酶的去磷酸化作用。
bioRxiv. 2024 Aug 8:2024.05.15.594272. doi: 10.1101/2024.05.15.594272.
3
Mechanical stretching of pulmonary vein stimulates matrix metalloproteinase-9 and transforming growth factor-β1 through stretch-activated channel/MAPK pathways in pulmonary hypertension due to left heart disease model rats.机械拉伸肺静脉通过牵张激活通道/MAPK 通路刺激基质金属蛋白酶-9 和转化生长因子-β1 在左心疾病模型大鼠肺动脉高压中。
PLoS One. 2020 Sep 3;15(9):e0235824. doi: 10.1371/journal.pone.0235824. eCollection 2020.
4
Involvement of p38 MAPK in Synaptic Function and Dysfunction.p38MAPK 在突触功能和功能障碍中的作用。
Int J Mol Sci. 2020 Aug 6;21(16):5624. doi: 10.3390/ijms21165624.
5
Crosstalk between mitogen-activated protein kinase inhibitors and transforming growth factor-β signaling results in variable activation of human dermal fibroblasts.丝裂原活化蛋白激酶抑制剂与转化生长因子-β信号通路的相互作用导致人真皮成纤维细胞的激活情况出现差异。
Int J Mol Med. 2019 Jan;43(1):325-335. doi: 10.3892/ijmm.2018.3949. Epub 2018 Oct 23.
6
SB202190 inhibits endothelial cell apoptosis via induction of autophagy and heme oxygenase-1.SB202190通过诱导自噬和血红素加氧酶-1来抑制内皮细胞凋亡。
Oncotarget. 2018 May 1;9(33):23149-23163. doi: 10.18632/oncotarget.25234.

本文引用的文献

1
Effect of Losmapimod on Cardiovascular Outcomes in Patients Hospitalized With Acute Myocardial Infarction: A Randomized Clinical Trial.洛马司他莫在急性心肌梗死后住院患者中的心血管结局影响：一项随机临床试验。
JAMA. 2016 Apr 19;315(15):1591-9. doi: 10.1001/jama.2016.3609.
2
Losmapimod, a novel p38 mitogen-activated protein kinase inhibitor, in non-ST-segment elevation myocardial infarction: a randomised phase 2 trial.洛司帕米莫，一种新型的 p38 丝裂原活化蛋白激酶抑制剂，在非 ST 段抬高型心肌梗死中的应用：一项随机 2 期试验。
Lancet. 2014 Sep 27;384(9949):1187-95. doi: 10.1016/S0140-6736(14)60417-7. Epub 2014 Jun 12.
3
Inflammation and its resolution as determinants of acute coronary syndromes.炎症及其消退作为急性冠脉综合征的决定因素。
Circ Res. 2014 Jun 6;114(12):1867-79. doi: 10.1161/CIRCRESAHA.114.302699.
4
Mechanisms of plaque formation and rupture.斑块形成和破裂的机制。
Circ Res. 2014 Jun 6;114(12):1852-66. doi: 10.1161/CIRCRESAHA.114.302721.
5
Therapeutic potential of p38 MAP kinase inhibition in the management of cardiovascular disease.p38丝裂原活化蛋白激酶抑制在心血管疾病管理中的治疗潜力。
Am J Cardiovasc Drugs. 2014 Jun;14(3):155-65. doi: 10.1007/s40256-014-0063-6.
6
New therapeutic targets in cardiology: p38 alpha mitogen-activated protein kinase for ischemic heart disease.心脏病学中的新治疗靶点：用于缺血性心脏病的p38α丝裂原活化蛋白激酶
Circulation. 2012 Jul 17;126(3):357-68. doi: 10.1161/CIRCULATIONAHA.111.071886.
7
The p38 mitogen-activated protein kinase pathway--a potential target for intervention in infarction, hypertrophy, and heart failure.p38 丝裂原活化蛋白激酶通路——干预梗死、肥大和心力衰竭的潜在靶点。
J Mol Cell Cardiol. 2011 Oct;51(4):485-90. doi: 10.1016/j.yjmcc.2010.10.021. Epub 2010 Nov 6.
8
Mitogen-activated protein kinase signaling in the heart: angels versus demons in a heart-breaking tale.心脏中的丝裂原活化蛋白激酶信号转导：一个心碎故事中的天使与恶魔。
Physiol Rev. 2010 Oct;90(4):1507-46. doi: 10.1152/physrev.00054.2009.
9
Successful structure-based design of recent p38 MAP kinase inhibitors.近期p38丝裂原活化蛋白激酶抑制剂基于结构的成功设计。
Curr Top Med Chem. 2009;9(7):655-76. doi: 10.2174/156802609789007363.
10
Sustained release of a p38 inhibitor from non-inflammatory microspheres inhibits cardiac dysfunction.p38抑制剂从非炎性微球中的持续释放可抑制心脏功能障碍。
Nat Mater. 2008 Nov;7(11):863-8. doi: 10.1038/nmat2299. Epub 2008 Oct 19.