• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

抗菌和抗真菌剂的研究，X. 1-（对甲基-α-[4-（1H-吡咯-1-基）苯基]苄基）唑类及一些相关产物的合成与抗真菌活性

Researches on antibacterial and antifungal agents, X. Synthesis and antifungal activities of 1-(p-methyl-alpha-[4-(1H-pyrrol-1-yl)phenyl]benzyl)azoles and some related products.

作者信息

Massa S, Stefancich G, Corelli F, Silvestri R, Mai A, Artico M, Panico S, Simonetti N

出版信息

Arch Pharm (Weinheim). 1989 Jun;322(6):369-73. doi: 10.1002/ardp.19893220609.

DOI:10.1002/ardp.19893220609
PMID:2774871
Abstract

The synthesis and antifungal activities against Candida albicans and Candida spp. of some pyrrole analogues of bifonazole are reported. 1-(p-Methyl-alpha-[4-(1H-pyrrol-1-yl)phenyl]benzyl)imidazole was found to be equipotent or sometimes superior to bifonazole and ketoconazole, and lightly inferior to miconazole. Substitution of the imidazole moiety with other azoles retained some activities. No activity was shown when the azole aromatic rings were replaced by the heteroalicyclic ones.

摘要

报道了联苯苄唑的一些吡咯类似物的合成及其对白色念珠菌和念珠菌属的抗真菌活性。发现1-(对甲基-α-[4-(1H-吡咯-1-基)苯基]苄基)咪唑与联苯苄唑和酮康唑效力相当，有时甚至优于它们，略逊于咪康唑。用其他唑类取代咪唑部分仍保留一些活性。当唑类芳香环被杂脂环取代时则无活性。

相似文献

1
Researches on antibacterial and antifungal agents, X. Synthesis and antifungal activities of 1-(p-methyl-alpha-[4-(1H-pyrrol-1-yl)phenyl]benzyl)azoles and some related products.抗菌和抗真菌剂的研究，X. 1-（对甲基-α-[4-（1H-吡咯-1-基）苯基]苄基）唑类及一些相关产物的合成与抗真菌活性
Arch Pharm (Weinheim). 1989 Jun;322(6):369-73. doi: 10.1002/ardp.19893220609.
2
Researches on antibacterial and antifungal agents. IX--Pyrrole analogues of bifonazole with potent antifungal activities.抗菌和抗真菌剂的研究。IX——具有强效抗真菌活性的联苯苄唑的吡咯类似物。
Farmaco Sci. 1988 Sep;43(9):693-704.
3
Researches on antibacterial and antifungal agents, XII: Analogues of bifonazole with two imidazole moieties and related azoles.
Arch Pharm (Weinheim). 1990 May;323(5):273-80. doi: 10.1002/ardp.19903230505.
4
Antifungal agents, II: Synthesis and antifungal activities of aryl-1H-pyrrol-2-yl-1H-imidazol-1-yl-methane derivatives with unsaturated chains.抗真菌剂，II：含不饱和链的芳基-1H-吡咯-2-基-1H-咪唑-1-基甲烷衍生物的合成及抗真菌活性
Arch Pharm (Weinheim). 1993 Sep;326(9):539-46. doi: 10.1002/ardp.19933260909.
5
Antifungal agents. 7. Dichlorophenylpyrrylimidazolylmethane derivatives: synthesis and antifungal activities.抗真菌剂。7. 二氯苯基吡咯并咪唑基甲烷衍生物：合成与抗真菌活性。
Farmaco. 1994 Jan;49(1):51-5.
6
Antifungal agents. 10. New derivatives of 1-[(aryl)[4-aryl-1H-pyrrol-3-yl]methyl]-1H-imidazole, synthesis, anti-candida activity, and quantitative structure-analysis relationship studies.抗真菌剂。10. 1-[(芳基)[4-芳基-1H-吡咯-3-基]甲基]-1H-咪唑的新衍生物、合成、抗念珠菌活性及定量构效关系研究
J Med Chem. 2002 Jun 20;45(13):2720-32. doi: 10.1021/jm011087h.
7
Antifungal agents. 11. N-substituted derivatives of 1-[(aryl)(4-aryl-1H-pyrrol-3-yl)methyl]-1H-imidazole: synthesis, anti-Candida activity, and QSAR studies.抗真菌剂。11. 1-[(芳基)(4-芳基-1H-吡咯-3-基)甲基]-1H-咪唑的N-取代衍生物：合成、抗念珠菌活性及定量构效关系研究
J Med Chem. 2005 Aug 11;48(16):5140-53. doi: 10.1021/jm048997u.
8
[Antibacterial and antifungal compounds. VIII. Synthesis and antifungal activity of pyrrol derivatives similar to trichostatin A].[抗菌和抗真菌化合物。VIII。与曲古抑菌素A类似的吡咯衍生物的合成及抗真菌活性]
Farmaco Sci. 1987 Dec;42(12):893-903.
9
[Antibacterial and antifungal compounds. V. Synthesis and antimicrobial activity of N-(2-arylethylaminophenyl)-1H-pyrryl-1-amine and 1-(1H-pyrrol-1-yl)-2-arylmethylbenzimidazole)].[抗菌和抗真菌化合物。V. N-(2-芳基乙氨基苯基)-1H-吡咯-1-胺和1-(1H-吡咯-1-基)-2-芳基甲基苯并咪唑的合成与抗菌活性]
Farmaco Sci. 1985 Jul;40(7):501-8.
10
Antifungal agents. 9. 3-Aryl-4-[alpha-(1H-imidazol-1-yl)arylmethyl]pyrroles: a new class of potent anti-Candida agents.抗真菌剂。9. 3-芳基-4-[α-(1H-咪唑-1-基)芳基甲基]吡咯：一类新型强效抗念珠菌剂。
J Med Chem. 1995 Oct 13;38(21):4223-33. doi: 10.1021/jm00021a011.