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[单胺能系统在雄激素对大鼠脑部分边缘结构神经元作用传递中的作用]

[Role of the monoaminergic system in the transmission of the effect of androgens on neurons of separate limbic structures of the rat brain].

作者信息

Myslitskiĭ V F

出版信息

Arkh Anat Gistol Embriol. 1989 May;96(5):23-5.

PMID:2774977
Abstract

By means of the histochemical method intensity of monoamines fluorescence has been studied in 3-, 5-, 7-, 10-, 20-, 30- and 60-day-old intact and neonatally androgenized female rats. The neonatal androgenization increases fluorescent intensity of monoamines in the neuropil of the adjoining nucleus of the septum, of the nucleus in the terminal stripe bed and the caudate nucleus. This is especially evident on the 3d, 7th and 30th days. On the 5th day of the postnatal life the difference in fluorescent intensity of monoamines in the brain of control and test animals is statistically insignificant. Possible mechanisms responsible for the fluorescent intensity of monoamines and the role of the latter in transmitting the sex hormones effect to the neurons of the forebrain structures investigated are discussed.

摘要

通过组织化学方法,研究了3日龄、5日龄、7日龄、10日龄、20日龄、30日龄和60日龄的未受干扰的和新生期雄激素化的雌性大鼠单胺荧光强度。新生期雄激素化增加了隔区邻接核、终纹床核和尾状核神经毡中单胺的荧光强度。这在第3天、第7天和第30天尤为明显。在出生后第5天,对照动物和受试动物大脑中单胺荧光强度的差异在统计学上不显著。讨论了单胺荧光强度的可能机制以及单胺在将性激素作用传递到所研究的前脑结构神经元中的作用。

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