Paulovic R P, Anwar R A
Department of Biochemistry, University of Toronto, Ontario, Canada.
Biochem J. 1989 Jul 1;261(1):227-32. doi: 10.1042/bj2610227.
The data presented clearly suggest that relative amounts of mRNAs for elastins a, b and c are developmentally regulated in foetal-calf nuchal ligament and aorta and that this regulation is tissue-specific. In nuchal ligament, at earlier stages of foetal development, the relative amounts of mRNAs for elastins a and b are very low. After the foetal age of about 6 months the relative amount of mRNA for elastin b begins to increase. This is followed by an increase in the relative amount of mRNA for elastin a. In aorta, with increasing foetal age, the relative amounts of mRNAs for elastins b and c increase and decrease alternately. The relative amounts of mRNA for elastin a remain low, with only marginal increases with foetal age. A possible self-aggregation role of elastin a in elastogenesis is proposed.
所呈现的数据清楚地表明，在胎牛项韧带和主动脉中，弹性蛋白a、b和c的mRNA相对含量在发育过程中受到调控，且这种调控具有组织特异性。在项韧带中，在胎儿发育的早期阶段，弹性蛋白a和b的mRNA相对含量非常低。在胎儿约6个月龄后，弹性蛋白b的mRNA相对含量开始增加。随后弹性蛋白a的mRNA相对含量增加。在主动脉中，随着胎儿年龄的增加，弹性蛋白b和c的mRNA相对含量交替增加和减少。弹性蛋白a的mRNA相对含量保持较低水平，仅随胎儿年龄有少量增加。有人提出弹性蛋白a在弹性蛋白生成中可能具有自我聚集作用。
